tetano
Editor, Senior Moderator
J Infect Dis. 2017 Nov 30. doi: 10.1093/infdis/jix512. [Epub ahead of print]
[h=1]Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.[/h] Makvandi-Nejad S[SUP]1[/SUP], Laurenson-Schafer H[SUP]1[/SUP], Wang L[SUP]1[/SUP], Wellington D[SUP]1[/SUP], Zhao Y[SUP]2,[/SUP][SUP]3[/SUP], Jin B[SUP]4[/SUP], Qin L[SUP]2,[/SUP][SUP]3[/SUP], Kite K[SUP]1[/SUP], Moghadam HK[SUP]5[/SUP], Song C[SUP]4[/SUP], Clark K[SUP]6[/SUP], Hublitz P[SUP]7[/SUP], Townsend AR[SUP]2[/SUP], Wu H[SUP]3[/SUP], McMichael AJ[SUP]1,[/SUP][SUP]2[/SUP], Zhang Y[SUP]2,[/SUP][SUP]3[/SUP], Dong T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes. Full-length IFITM3 protein can be detected in all genotypes.
[h=4]KEYWORDS:[/h] IFITM3; influenza A virus; rs12252
PMID: 29202190 DOI: 10.1093/infdis/jix512
[h=1]Lack of Truncated IFITM3 Transcripts in Cells Homozygous for the rs12252-C Variant That is Associated With Severe Influenza Infection.[/h] Makvandi-Nejad S[SUP]1[/SUP], Laurenson-Schafer H[SUP]1[/SUP], Wang L[SUP]1[/SUP], Wellington D[SUP]1[/SUP], Zhao Y[SUP]2,[/SUP][SUP]3[/SUP], Jin B[SUP]4[/SUP], Qin L[SUP]2,[/SUP][SUP]3[/SUP], Kite K[SUP]1[/SUP], Moghadam HK[SUP]5[/SUP], Song C[SUP]4[/SUP], Clark K[SUP]6[/SUP], Hublitz P[SUP]7[/SUP], Townsend AR[SUP]2[/SUP], Wu H[SUP]3[/SUP], McMichael AJ[SUP]1,[/SUP][SUP]2[/SUP], Zhang Y[SUP]2,[/SUP][SUP]3[/SUP], Dong T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes. Full-length IFITM3 protein can be detected in all genotypes.
[h=4]KEYWORDS:[/h] IFITM3; influenza A virus; rs12252
PMID: 29202190 DOI: 10.1093/infdis/jix512