Ansakorpi H, Rusanen H, Rytky S, F?rkkil? M. Lambert?Eaton myasthenic syndrome following H1N1-influenza vaccination ? a case report. Acta Neurol Scand 2012: 126: e25-e28. DOI: 10.1111/j.1600-0404.2012.01675.x. ? 2012 John Wiley & Sons A/S. [h=3]Keywords:[/h]
- Lambert?Eaton myasthenic syndrome;
- H1N1 virus;
- vaccination;
- autoimmune diseases, nervous system;
- adjuvants, immunological
[h=4]Background[/h] The outbreak of influenza A (H1N1) pandemic during the year 2009 led to the development of several vaccinations against H1N1 virus. In Finland, 2.6 million citizens were vaccinated during pandemic 2009 ? 2010 with adjuvanted influenza vaccine, Pandemrix[SUP]?[/SUP].
[h=4]Clinical Presentation[/h] In this case report, we describe a patient with non-paraneoplastic Lambert?Eaton myasthenic syndrome following Pandemrix[SUP]?[/SUP] vaccination.
[h=4]Conclusion[/h] Development of various autoimmune diseases in genetically predisposed subjects following exposure to certain environmental factors, including vaccinations, is a well-known entity. Clinicians should be aware of the possibility of the induction of autoimmune diseases following vaccinations and actively ask the relevant clinical history in a newly diagnosed patient with an autoimmune disorder.
