tetano
Editor, Senior Moderator
Elife. 2015 Aug 7;4. doi: 10.7554/eLife.07467. [Epub ahead of print]
[h=1]Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity.[/h] Altman MO[SUP]1[/SUP], Bennink JR[SUP]1[/SUP], Yewdell JW[SUP]1[/SUP], Herrin BR[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses ~80% of the response on hemagglutinin, mainly through recognition of the major antigenic sites in the hemagglutinin globular head domain. Our findings predict basic conservation of antibody responses to protein antigens, strongly supporting the use of animal models for understanding human antibody responses to viruses and protein immunogens.
[h=4]KEYWORDS:[/h] antibodies; antigenicity; hemagglutinin; immunodominance; immunology; infectious disease; influenza; lamprey; microbiology; mouse
PMID: 26252514 [PubMed - as supplied by publisher]
[h=1]Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity.[/h] Altman MO[SUP]1[/SUP], Bennink JR[SUP]1[/SUP], Yewdell JW[SUP]1[/SUP], Herrin BR[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made organic molecules. Jawless vertebrates evolved a parallel system of humoral immunity, which recognizes antigens not with Ig, but with a structurally unrelated receptor called the variable lymphocyte receptor B (VLRB). We exploited the convergent evolution of Ig and VLRB antibodies to investigate if intrinsic chemical features of foreign proteins determine their antigenicity and immunogenicity. Surprisingly, we find lamprey VLRB and mouse Ig responses to influenza A virus are extremely similar. Each focuses ~80% of the response on hemagglutinin, mainly through recognition of the major antigenic sites in the hemagglutinin globular head domain. Our findings predict basic conservation of antibody responses to protein antigens, strongly supporting the use of animal models for understanding human antibody responses to viruses and protein immunogens.
[h=4]KEYWORDS:[/h] antibodies; antigenicity; hemagglutinin; immunodominance; immunology; infectious disease; influenza; lamprey; microbiology; mouse
PMID: 26252514 [PubMed - as supplied by publisher]