tetano
Editor, Senior Moderator
Lancet Glob Health. 2016 Oct 13. pii: S2214-109X(16)30200-5. doi: 10.1016/S2214-109X(16)30200-5. [Epub ahead of print]
Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial.
Brooks WA[SUP]1[/SUP], Zaman K[SUP]2[/SUP], Lewis KD[SUP]3[/SUP], Ortiz JR[SUP]4[/SUP], Goswami D[SUP]2[/SUP], Feser J[SUP]3[/SUP], Sharmeen AT[SUP]2[/SUP], Nahar K[SUP]2[/SUP], Rahman M[SUP]2[/SUP], Rahman MZ[SUP]2[/SUP], Barin B[SUP]5[/SUP], Yunus M[SUP]2[/SUP], Fry AM[SUP]6[/SUP], Bresee J[SUP]6[/SUP], Azim T[SUP]2[/SUP], Neuzil KM[SUP]7[/SUP].
Author information
Abstract
BACKGROUND:
The rates of influenza illness and associated complications are high among children in Bangladesh. We assessed the clinical efficacy and safety of a Russian-backbone live attenuated influenza vaccine (LAIV) at two field sites in Bangladesh.
METHODS:
Between Feb 27 and April 9, 2013, children aged 2-4 years in urban Kamalapur and rural Matlab, Bangladesh, were randomly assigned in a 2:1 ratio, according to a computer-generated schedule, to receive one intranasal dose of LAIV or placebo. After vaccination, we monitored children in weekly home visits until Dec 31, 2013, with study clinic surveillance for influenza illness. The primary outcome was symptomatic, laboratory-confirmed influenza illness due to vaccine-matched strains. Analysis was per protocol. The trial is registered with ClinicalTrials.gov, number NCT01797029.
FINDINGS:
Of 1761 children enrolled, 1174 received LAIV and 587 received placebo. Laboratory-confirmed influenza illness due to vaccine-matched strains was seen in 93 (15?8%) children in the placebo group and 79 (6?7%) in the LAIV group. Vaccine efficacy of LAIV for vaccine-matched strains was 57?5% (95% CI 43?6-68?0). The vaccine was well tolerated, and adverse events were balanced between the groups. The most frequent adverse events were tachypnoea (n=86 in the LAIV group and n=54 in the placebo group), cough (n=73 and n=43), and runny nose (n=68 and n=39), most of which were mild.
INTERPRETATION:
This single-dose Russian-backbone LAIV was safe and efficacious at preventing symptomatic laboratory-confirmed influenza illness due to vaccine-matched strains. LAIV programmes might reduce the burden of influenza illness in Bangladesh.
FUNDING:
The Bill & Melinda Gates Foundation.
Copyright ? 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.
PMID: 27746226 DOI: 10.1016/S2214-109X(16)30200-5
[PubMed - as supplied by publisher] Free full text
Efficacy of a Russian-backbone live attenuated influenza vaccine among young children in Bangladesh: a randomised, double-blind, placebo-controlled trial.
Brooks WA[SUP]1[/SUP], Zaman K[SUP]2[/SUP], Lewis KD[SUP]3[/SUP], Ortiz JR[SUP]4[/SUP], Goswami D[SUP]2[/SUP], Feser J[SUP]3[/SUP], Sharmeen AT[SUP]2[/SUP], Nahar K[SUP]2[/SUP], Rahman M[SUP]2[/SUP], Rahman MZ[SUP]2[/SUP], Barin B[SUP]5[/SUP], Yunus M[SUP]2[/SUP], Fry AM[SUP]6[/SUP], Bresee J[SUP]6[/SUP], Azim T[SUP]2[/SUP], Neuzil KM[SUP]7[/SUP].
Author information
Abstract
BACKGROUND:
The rates of influenza illness and associated complications are high among children in Bangladesh. We assessed the clinical efficacy and safety of a Russian-backbone live attenuated influenza vaccine (LAIV) at two field sites in Bangladesh.
METHODS:
Between Feb 27 and April 9, 2013, children aged 2-4 years in urban Kamalapur and rural Matlab, Bangladesh, were randomly assigned in a 2:1 ratio, according to a computer-generated schedule, to receive one intranasal dose of LAIV or placebo. After vaccination, we monitored children in weekly home visits until Dec 31, 2013, with study clinic surveillance for influenza illness. The primary outcome was symptomatic, laboratory-confirmed influenza illness due to vaccine-matched strains. Analysis was per protocol. The trial is registered with ClinicalTrials.gov, number NCT01797029.
FINDINGS:
Of 1761 children enrolled, 1174 received LAIV and 587 received placebo. Laboratory-confirmed influenza illness due to vaccine-matched strains was seen in 93 (15?8%) children in the placebo group and 79 (6?7%) in the LAIV group. Vaccine efficacy of LAIV for vaccine-matched strains was 57?5% (95% CI 43?6-68?0). The vaccine was well tolerated, and adverse events were balanced between the groups. The most frequent adverse events were tachypnoea (n=86 in the LAIV group and n=54 in the placebo group), cough (n=73 and n=43), and runny nose (n=68 and n=39), most of which were mild.
INTERPRETATION:
This single-dose Russian-backbone LAIV was safe and efficacious at preventing symptomatic laboratory-confirmed influenza illness due to vaccine-matched strains. LAIV programmes might reduce the burden of influenza illness in Bangladesh.
FUNDING:
The Bill & Melinda Gates Foundation.
Copyright ? 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.
PMID: 27746226 DOI: 10.1016/S2214-109X(16)30200-5
[PubMed - as supplied by publisher] Free full text