tetano
Editor, Senior Moderator
Lancet Reg Health Am
. 2025 Apr 28:46:101100.
doi: 10.1016/j.lana.2025.101100. eCollection 2025 Jun. Enhancing the response to avian influenza in the US and globally
Maggie L Bartlett[SUP] 1 2 [/SUP], Peter Palese[SUP] 3 1 [/SUP], Meghan F Davis[SUP] 2 1 [/SUP], Sten H Vermund[SUP] 1 4 [/SUP], Christian Bréchot[SUP] 1 4 [/SUP], Jared D Evans[SUP] 5 1 [/SUP], Lauren M Sauer[SUP] 5 1 [/SUP], Albert Osterhaus[SUP] 6 1 [/SUP], Andrew Pekosz[SUP] 2 1 [/SUP], Martha Nelson[SUP] 7 1 [/SUP], Elyse Stachler[SUP] 8 1 [/SUP], Florian Krammer[SUP] 9 1 [/SUP], Gage Moreno[SUP] 8 1 [/SUP], Gene Olinger[SUP] 10 1 [/SUP], Marion Koopmans[SUP] 11 1 [/SUP]
Affiliations
The recent emergence of highly pathogenic H5N1 avian influenza virus infections in dairy cows and humans in the U.S. has raised alarms regarding the potential for a pandemic. Over 995 dairy cow herds and at least 70 humans have been affected, including cases of severe disease and the first reported H5N1-related death in the U.S. Sporadic human infections with no known contact with infected animals highlight the possibility of viral adaptation for efficient human-to-human transmission. Concurrently, the virus continues to circulate in wild birds, backyard flocks, and hunted migratory species, further amplifying the risk to humans and domestic animals. This article provides an overview of the current outbreak status, emphasizes the importance of robust surveillance systems to detect emerging strains with pandemic potential, and highlights risks to the U.S. dairy and poultry industries. Recommendations for risk mitigation include enhanced biosecurity measures, improved surveillance, decentralized testing, and targeted public health messaging. The Global Virus Network calls for urgent, proactive measures to prevent widespread outbreaks, leveraging lessons learned from prior pandemics. These measures include targeted vaccination, improved communication strategies to combat vaccine hesitancy, and the incorporation of social sciences to address barriers to public health interventions.
Keywords: Global health; H5N1; Surveillance.
. 2025 Apr 28:46:101100.
doi: 10.1016/j.lana.2025.101100. eCollection 2025 Jun. Enhancing the response to avian influenza in the US and globally
Maggie L Bartlett[SUP] 1 2 [/SUP], Peter Palese[SUP] 3 1 [/SUP], Meghan F Davis[SUP] 2 1 [/SUP], Sten H Vermund[SUP] 1 4 [/SUP], Christian Bréchot[SUP] 1 4 [/SUP], Jared D Evans[SUP] 5 1 [/SUP], Lauren M Sauer[SUP] 5 1 [/SUP], Albert Osterhaus[SUP] 6 1 [/SUP], Andrew Pekosz[SUP] 2 1 [/SUP], Martha Nelson[SUP] 7 1 [/SUP], Elyse Stachler[SUP] 8 1 [/SUP], Florian Krammer[SUP] 9 1 [/SUP], Gage Moreno[SUP] 8 1 [/SUP], Gene Olinger[SUP] 10 1 [/SUP], Marion Koopmans[SUP] 11 1 [/SUP]
Affiliations
- PMID: 40625789
- PMCID: PMC12230410
- DOI: 10.1016/j.lana.2025.101100
The recent emergence of highly pathogenic H5N1 avian influenza virus infections in dairy cows and humans in the U.S. has raised alarms regarding the potential for a pandemic. Over 995 dairy cow herds and at least 70 humans have been affected, including cases of severe disease and the first reported H5N1-related death in the U.S. Sporadic human infections with no known contact with infected animals highlight the possibility of viral adaptation for efficient human-to-human transmission. Concurrently, the virus continues to circulate in wild birds, backyard flocks, and hunted migratory species, further amplifying the risk to humans and domestic animals. This article provides an overview of the current outbreak status, emphasizes the importance of robust surveillance systems to detect emerging strains with pandemic potential, and highlights risks to the U.S. dairy and poultry industries. Recommendations for risk mitigation include enhanced biosecurity measures, improved surveillance, decentralized testing, and targeted public health messaging. The Global Virus Network calls for urgent, proactive measures to prevent widespread outbreaks, leveraging lessons learned from prior pandemics. These measures include targeted vaccination, improved communication strategies to combat vaccine hesitancy, and the incorporation of social sciences to address barriers to public health interventions.
Keywords: Global health; H5N1; Surveillance.