tetano
Editor, Senior Moderator
Laryngoscope
. 2021 Nov 23.
doi: 10.1002/lary.29964. Online ahead of print.
New onset of smell and taste loss are common findings also in patients with symptomatic COVID-19 after complete vaccination
Luigi Angelo Vaira[SUP] 1 2 [/SUP], Andrea De Vito[SUP] 3 [/SUP], Jerome R Lechien[SUP] 4 5 [/SUP], Carlos Miguel Chiesa-Estomba[SUP] 4 6 [/SUP], Miguel Mayo-Yàñez[SUP] 7 [/SUP], Christian Calvo-Henrìquez[SUP] 8 [/SUP], Sven Saussez[SUP] 4 5 [/SUP], Giordano Madeddu[SUP] 3 [/SUP], Sergio Babudieri[SUP] 3 [/SUP], Paolo Boscolo-Rizzo[SUP] 9 [/SUP], Claire Hopkins[SUP] 10 [/SUP], Giacomo De Riu[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: To investigate the clinical profile of patients who developed coronavirus disease 2019 (COVID-19) after full vaccination.
Methods: Demographic, epidemiological and clinical data were collected through medical records and online patient-reported outcome questionnaire from patients who developed symptomatic SARS-CoV-2 infection, confirmed by nasopharyngeal swab, at least two weeks after completion of vaccination.
Results: 153 subjects were included. The most frequent symptoms were: asthenia (82.4%), chemosensory dysfunction (63.4%), headache (59.5%), runny nose (58.2%), muscle pain (54.9%), loss of appetite (54.3%) and nasal obstruction (51.6%). Particularly, 62.3% and 53.6% of subjects reported olfactory and gustatory dysfunction, respectively. Symptom severity was mild or moderate in almost all cases.
Conclusions: Chemosensory dysfunctions have been observed to be a frequent symptom even in subjects who contracted the infection after full vaccination. For this reason, the sudden loss of smell and taste could continue to represent a useful and specific diagnostic marker to raise the suspicion of COVID-19 even in vaccinated subjects. In the future, it will be necessary to establish what the recovery rate is in these patients.
Keywords: COVID-19; ageusia; anosmia; gustatory dysfunction; olfactory dysfunction; vaccination.
. 2021 Nov 23.
doi: 10.1002/lary.29964. Online ahead of print.
New onset of smell and taste loss are common findings also in patients with symptomatic COVID-19 after complete vaccination
Luigi Angelo Vaira[SUP] 1 2 [/SUP], Andrea De Vito[SUP] 3 [/SUP], Jerome R Lechien[SUP] 4 5 [/SUP], Carlos Miguel Chiesa-Estomba[SUP] 4 6 [/SUP], Miguel Mayo-Yàñez[SUP] 7 [/SUP], Christian Calvo-Henrìquez[SUP] 8 [/SUP], Sven Saussez[SUP] 4 5 [/SUP], Giordano Madeddu[SUP] 3 [/SUP], Sergio Babudieri[SUP] 3 [/SUP], Paolo Boscolo-Rizzo[SUP] 9 [/SUP], Claire Hopkins[SUP] 10 [/SUP], Giacomo De Riu[SUP] 1 [/SUP]
Affiliations
- PMID: 34812498
- DOI: 10.1002/lary.29964
Abstract
Objective: To investigate the clinical profile of patients who developed coronavirus disease 2019 (COVID-19) after full vaccination.
Methods: Demographic, epidemiological and clinical data were collected through medical records and online patient-reported outcome questionnaire from patients who developed symptomatic SARS-CoV-2 infection, confirmed by nasopharyngeal swab, at least two weeks after completion of vaccination.
Results: 153 subjects were included. The most frequent symptoms were: asthenia (82.4%), chemosensory dysfunction (63.4%), headache (59.5%), runny nose (58.2%), muscle pain (54.9%), loss of appetite (54.3%) and nasal obstruction (51.6%). Particularly, 62.3% and 53.6% of subjects reported olfactory and gustatory dysfunction, respectively. Symptom severity was mild or moderate in almost all cases.
Conclusions: Chemosensory dysfunctions have been observed to be a frequent symptom even in subjects who contracted the infection after full vaccination. For this reason, the sudden loss of smell and taste could continue to represent a useful and specific diagnostic marker to raise the suspicion of COVID-19 even in vaccinated subjects. In the future, it will be necessary to establish what the recovery rate is in these patients.
Keywords: COVID-19; ageusia; anosmia; gustatory dysfunction; olfactory dysfunction; vaccination.