tetano
Editor, Senior Moderator
Curr Top Microbiol Immunol. 2014 Jul 25. [Epub ahead of print]
Live Attenuated Influenza Vaccine.
Jin H1, Subbarao K.
Author information
Abstract
Cold-adapted Ann Arbor based live attenuated influenza vaccine (LAIVLAIV ) has been available in the USA since 2003. The vaccine is efficacious against influenza infection. Features of LAIV include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of influenza spread. Annual seasonal LAIV now contains four strains against influenza A H1N1, H3N2, influenza B-Victoria, and B-Yamagata lineages that are co-circulating in humans. LAIV played a significant role in protecting the public from the 2009 H1N1 pandemic and has been evaluated for pandemic preparedness. Pandemic vaccinesPandemic vaccines including influenza H2H2 , H5H5 , H6H6 , H7H7 , and H9H9 subtypes have been produced and evaluated in preclinical and small-scale phase I clinical studies. This review summarizes the current status and perspectives of seasonal and pandemic LAIV.
PMID:
25059893
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25059893
Live Attenuated Influenza Vaccine.
Jin H1, Subbarao K.
Author information
Abstract
Cold-adapted Ann Arbor based live attenuated influenza vaccine (LAIVLAIV ) has been available in the USA since 2003. The vaccine is efficacious against influenza infection. Features of LAIV include: easy administration suitable for mass immunization, cross-reactivity to drifted strains for broader coverage, and establishment of herd immunity for control of influenza spread. Annual seasonal LAIV now contains four strains against influenza A H1N1, H3N2, influenza B-Victoria, and B-Yamagata lineages that are co-circulating in humans. LAIV played a significant role in protecting the public from the 2009 H1N1 pandemic and has been evaluated for pandemic preparedness. Pandemic vaccinesPandemic vaccines including influenza H2H2 , H5H5 , H6H6 , H7H7 , and H9H9 subtypes have been produced and evaluated in preclinical and small-scale phase I clinical studies. This review summarizes the current status and perspectives of seasonal and pandemic LAIV.
PMID:
25059893
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25059893