tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2016 Jul 14. pii: S1198-743X(16)30215-4. doi: 10.1016/j.cmi.2016.06.015. [Epub ahead of print]
[h=1]Long term detection of seasonal influenza RNA in faeces and intestine.[/h] Hirose R[SUP]1[/SUP], Daidoji T[SUP]2[/SUP], Naito Y[SUP]3[/SUP], Watanabe Y[SUP]4[/SUP], Arai Y[SUP]5[/SUP], Oda T[SUP]6[/SUP], Konishi H[SUP]3[/SUP], Yamawaki M[SUP]7[/SUP], Itoh Y[SUP]3[/SUP], Nakaya T[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Some cases of seasonal influenza virus (IAV/IBV) are associated with abdominal symptoms. Although viral RNA has been detected in faeces, intestinal infection has not been clearly demonstrated. We aimed to provide evidence that IAV/IBV infects the human intestine.
[h=4]METHODS:[/h] This prospective observational study measured viral RNA in faecal and sputum samples from 22 patients infected with IAV/IBV (19 IAV-positive and three IBV-positive). Nineteen patients were included in the analysis and assigned to "faecal IAV-positive" and "-negative" groups. Viral kinetics were examined in faecal samples from an IAV-infected patient (Case 1) and an IBV-infected patient (Case 2). Finally, intestinal tissue from an IAV-diagnosed patient, who developed haemorrhagic colitis and underwent colonoscopy, was examined for the presence of replicating IAV (Case 3).
[h=4]RESULTS:[/h] Viral RNA was detected in faecal samples from 8/22 IAV/IBV-infected patients (36.4%). Diarrhoea occurred significantly more often in the faecal IAV-positive group (P = 0.002). In Cases 1 and 2, viral RNA became undetectable in sputum on Days 7 and 10 post-infection, respectively, but was detected in faeces for a further 2 weeks. Viral mRNA and antigens were detected in intestinal tissues (mucosal epithelium of the sigmoid colon) from Case 3.
[h=4]CONCLUSIONS:[/h] These findings suggest that IAV/IBV infects within the intestinal tract; thus, the human intestine may be an additional target organ for IAV/IBV infection.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] colitis; colonoscopy; faeces; influenza; intestine
PMID: 27424942 DOI: 10.1016/j.cmi.2016.06.015
[PubMed - as supplied by publisher]
[h=1]Long term detection of seasonal influenza RNA in faeces and intestine.[/h] Hirose R[SUP]1[/SUP], Daidoji T[SUP]2[/SUP], Naito Y[SUP]3[/SUP], Watanabe Y[SUP]4[/SUP], Arai Y[SUP]5[/SUP], Oda T[SUP]6[/SUP], Konishi H[SUP]3[/SUP], Yamawaki M[SUP]7[/SUP], Itoh Y[SUP]3[/SUP], Nakaya T[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Some cases of seasonal influenza virus (IAV/IBV) are associated with abdominal symptoms. Although viral RNA has been detected in faeces, intestinal infection has not been clearly demonstrated. We aimed to provide evidence that IAV/IBV infects the human intestine.
[h=4]METHODS:[/h] This prospective observational study measured viral RNA in faecal and sputum samples from 22 patients infected with IAV/IBV (19 IAV-positive and three IBV-positive). Nineteen patients were included in the analysis and assigned to "faecal IAV-positive" and "-negative" groups. Viral kinetics were examined in faecal samples from an IAV-infected patient (Case 1) and an IBV-infected patient (Case 2). Finally, intestinal tissue from an IAV-diagnosed patient, who developed haemorrhagic colitis and underwent colonoscopy, was examined for the presence of replicating IAV (Case 3).
[h=4]RESULTS:[/h] Viral RNA was detected in faecal samples from 8/22 IAV/IBV-infected patients (36.4%). Diarrhoea occurred significantly more often in the faecal IAV-positive group (P = 0.002). In Cases 1 and 2, viral RNA became undetectable in sputum on Days 7 and 10 post-infection, respectively, but was detected in faeces for a further 2 weeks. Viral mRNA and antigens were detected in intestinal tissues (mucosal epithelium of the sigmoid colon) from Case 3.
[h=4]CONCLUSIONS:[/h] These findings suggest that IAV/IBV infects within the intestinal tract; thus, the human intestine may be an additional target organ for IAV/IBV infection.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] colitis; colonoscopy; faeces; influenza; intestine
PMID: 27424942 DOI: 10.1016/j.cmi.2016.06.015
[PubMed - as supplied by publisher]