Outbreaks and Emergencies Bulletin, Week 39: 22 - 28 September 2018
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Plague Madagascar
25
Cases
6
Deaths
24%
CFR
EVENT DESCRIPTION
On 19 August 2018 (week 34), a suspected case of bubonic plague was
reported from Ankazobe district, a plague endemic area in the central
highlands, where the last epidemic started in August 2017. This initial
case was a 41-year-old male living in the rural community of Fiadanana.
He was confirmed by polymerase chain reaction (PCR) and culture at
Institut Pasteur de Madagascar (IPM) and is currently being treated.
Subsequently, additional suspected bubonic and pneumonic cases were
reported from five endemic regions in central highlands.
As of 27 September 2018 (week 39), a total of 25 cumulative cases
including five community deaths (case fatality ratio 20%) have been
reported from nine districts across five endemic regions, namely, HauteMatsiatra,
Amoron?I Mania, Itasy, Vakinankaratra, and Analamanga. Six
of these 25 suspected cases have been laboratory confirmed by RDT,
PCR and/or culture at IPM (three pneumonic and three bubonic cases)
and 19 are currently classified as suspected cases. Four of the five deaths
were reported among confirmed cases; three in confirmed pneumonic
cases and one in confirmed bubonic cases. The six confirmed cases
have been reported across four regions: Analamanga (2 cases), Haute
Matsiatra (1 case), Itasy (2 cases) and Amoron?I Mania (1 case) regions.
Among the remaining 19 suspected cases, 10 (53%) presented clinical
signs compatible with pneumonic plague, while 9 (47%) had a clinical
presentation of bubonic plague.
The first confirmed pneumonic case was a 36-year-old female from
Ambalavao district, Haute Matsiatra region in the central highlands.
She developed respiratory symptoms on 5 September 2018 and died
on 7 September 2018 in the community. The last two confirmed cases
of pneumonic plague were a couple from Miarinarivo district, in Itasy
region. The husband, aged 38 years, developed severe respiratory
symptoms on 15 September 2018 and died on 18 September 2018. Prior
to his death, he participated in a religious gathering on 14 September
2018 in Analavory town, Miarinarivo district. His 24-year-old wife, died
one hour after his death, following symptom onset on 16 September
2018. All confirmed pneumonic cases were confirmed post-mortem
and are currently classified as primary pneumonic plague cases; their
contacts are currently under follow-up.
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SITUATION INTERPRETATION
Plague is endemic on the Plateaux of Madagascar. Cases are typically recorded from September to April. Although bubonic cases are predominantly reported during the endemic season, pneumonic cases are also expected and are associated with human-to-human transmission and a high case fatality of 30-100% if left untreated. The recently notified cases of confirmed pneumonic cases have been reported from endemic and non-overcrowded areas so far. However, deaths among these cases have occurred in the community. There is currently no information concerning the source of infection of the three confirmed pneumonic cases. But, given their classification as primary pneumonic plague cases, it is important to investigate potential unidentified transmission chains in order to mitigate the risk of spread of the disease to other districts and major urban centres. Madagascar is experienced in the management of plague outbreaks. Further spread of the disease to highly populated cities could be prevented by strengthening preparedness and readiness activities in districts neighbouring the affected areas and at entry points, scaling up infection prevention including safe burials and vector control, enhancing community engagement, strengthening epidemiologic surveillance and ensuring early linkage to care in the affected areas. National and international authorities need to act swiftly to put these measures in place.
http://apps.who.int/iris/bitstream/h...2228092018.pdf
https://afro.who.int/publications/ou...september-2018