tetano
Editor, Senior Moderator
Vaccines (Basel). 2019 Dec 13;7(4). pii: E215. doi: 10.3390/vaccines7040215. [h=1]Mapping Host-Related Correlates of Influenza Vaccine-Induced Immune Response: An Umbrella Review of the Available Systematic Reviews and Meta-Analyses.[/h]
Domnich A[SUP]1[/SUP], Manini I[SUP]1[/SUP], Calabr? GE[SUP]2[/SUP], Waure C[SUP]3[/SUP], Montomoli E[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. 2 Section of Hygiene, Institute of Public Health, Universit? Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy. 3 Department of Experimental Medicine, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy. 4 VisMederi Life Science research, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy.
[h=3]Abstract[/h] Seasonal influenza is the leading infectious disease in terms of its health and socioeconomic impact. Annual immunization is the most efficient way to reduce this burden. Several correlates of influenza vaccine-induced protection are commonly used, owing to their ready availability and cheapness. Influenza vaccine-induced immunogenicity is a function of host-, virus- and vaccine-related factors. Host-related factors constitute the most heterogeneous group. The objective of this study was to analyze the available systematic evidence on the host factors able to modify influenza vaccine-induced immunogenicity. An umbrella review approach was undertaken. A total of 28 systematic reviews/meta-analyses were analyzed-these covered the following domains: intravenous drug use, psychological stress, acute and chronic physical exercise, genetic polymorphisms, use of pre-/pro-/symbiotics, previous Bacillus Calmette-Gu?rin vaccination, diabetes mellitus, vitamin D supplementation/deficiency, latent cytomegalovirus infection and various forms of immunosuppression. In order to present effect sizes on the same scale, all possible meta-analyses were re-performed and cumulative evidence synthesis ranking was carried out. The meta-analysis was conducted separately on each health condition category and virus (sub)type. A total of 97 pooled estimates were used in order to construct an evidence-based stakeholder-friendly map. The principal public health implications are discussed.
[h=4]KEYWORDS:[/h] correlates of protection; hemagglutination inhibition; immunogenicity; influenza; influenza vaccines; umbrella review; vaccination; vaccines
PMID: 31847273 DOI: 10.3390/vaccines7040215
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Domnich A[SUP]1[/SUP], Manini I[SUP]1[/SUP], Calabr? GE[SUP]2[/SUP], Waure C[SUP]3[/SUP], Montomoli E[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 Department of Molecular and Developmental Medicine, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. 2 Section of Hygiene, Institute of Public Health, Universit? Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy. 3 Department of Experimental Medicine, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy. 4 VisMederi Life Science research, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy.
[h=3]Abstract[/h] Seasonal influenza is the leading infectious disease in terms of its health and socioeconomic impact. Annual immunization is the most efficient way to reduce this burden. Several correlates of influenza vaccine-induced protection are commonly used, owing to their ready availability and cheapness. Influenza vaccine-induced immunogenicity is a function of host-, virus- and vaccine-related factors. Host-related factors constitute the most heterogeneous group. The objective of this study was to analyze the available systematic evidence on the host factors able to modify influenza vaccine-induced immunogenicity. An umbrella review approach was undertaken. A total of 28 systematic reviews/meta-analyses were analyzed-these covered the following domains: intravenous drug use, psychological stress, acute and chronic physical exercise, genetic polymorphisms, use of pre-/pro-/symbiotics, previous Bacillus Calmette-Gu?rin vaccination, diabetes mellitus, vitamin D supplementation/deficiency, latent cytomegalovirus infection and various forms of immunosuppression. In order to present effect sizes on the same scale, all possible meta-analyses were re-performed and cumulative evidence synthesis ranking was carried out. The meta-analysis was conducted separately on each health condition category and virus (sub)type. A total of 97 pooled estimates were used in order to construct an evidence-based stakeholder-friendly map. The principal public health implications are discussed.
[h=4]KEYWORDS:[/h] correlates of protection; hemagglutination inhibition; immunogenicity; influenza; influenza vaccines; umbrella review; vaccination; vaccines
PMID: 31847273 DOI: 10.3390/vaccines7040215
Free full text