tetano
Editor, Senior Moderator
Medicina (Kaunas)
. 2020 Oct 5;56(10):E521.
doi: 10.3390/medicina56100521.
Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report
Po-I Huang[SUP] 1 [/SUP], Ting-Chun Lin[SUP] 2 [/SUP], Feng-Cheng Liu[SUP] 3 [/SUP], Yi-Jung Ho[SUP] 2 4 [/SUP], Jeng-Wei Lu[SUP] 5 [/SUP], Te-Yu Lin[SUP] 6 [/SUP]
Affiliations
Abstract
The clinical spectrum of novel coronavirus infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia, with respiratory failure and even death. Autoantibodies, especially antiphospholipid antibodies, can occur in severe infections. Other autoantibodies are seldom reported. Here, a 60-year-old female patient without dry-mouth symptoms detected positive for anti-60 kDa SSA/Ro antibodies on day 43 after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To investigate this unique clinical case of SARS-CoV-2 infection, immunological characteristics of this case were detected by using flow cytometry and were compared to the other three groups of patients-health subjects, 2019 novel coronavirus disease (COVID-19) recovery patients, and Sj?gren's syndrome (SS) patients. Monitoring the autoantibody level and the development of subsequently related autoimmune diseases are warranted after SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; Sj?gren’s syndrome; autoimmune; immunophenotyping.
. 2020 Oct 5;56(10):E521.
doi: 10.3390/medicina56100521.
Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report
Po-I Huang[SUP] 1 [/SUP], Ting-Chun Lin[SUP] 2 [/SUP], Feng-Cheng Liu[SUP] 3 [/SUP], Yi-Jung Ho[SUP] 2 4 [/SUP], Jeng-Wei Lu[SUP] 5 [/SUP], Te-Yu Lin[SUP] 6 [/SUP]
Affiliations
- PMID: 33028028
- DOI: 10.3390/medicina56100521
Abstract
The clinical spectrum of novel coronavirus infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia, with respiratory failure and even death. Autoantibodies, especially antiphospholipid antibodies, can occur in severe infections. Other autoantibodies are seldom reported. Here, a 60-year-old female patient without dry-mouth symptoms detected positive for anti-60 kDa SSA/Ro antibodies on day 43 after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To investigate this unique clinical case of SARS-CoV-2 infection, immunological characteristics of this case were detected by using flow cytometry and were compared to the other three groups of patients-health subjects, 2019 novel coronavirus disease (COVID-19) recovery patients, and Sj?gren's syndrome (SS) patients. Monitoring the autoantibody level and the development of subsequently related autoimmune diseases are warranted after SARS-CoV-2 infection.
Keywords: COVID-19; SARS-CoV-2; Sj?gren’s syndrome; autoimmune; immunophenotyping.