tetano
Editor, Senior Moderator
Medicina (Kaunas)
. 2021 Mar 20;57(3):290.
doi: 10.3390/medicina57030290.
SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples
Barbara Brogna[SUP] 1 [/SUP], Carlo Brogna[SUP] 2 [/SUP], Mauro Petrillo[SUP] 3 [/SUP], Adriana Modestina Conte[SUP] 4 [/SUP], Giulio Benincasa[SUP] 5 [/SUP], Luigi Montano[SUP] 6 [/SUP], Marina Piscopo[SUP] 7 [/SUP]
Affiliations
Abstract
Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests' results on samples from the upper respiratory tract.
Keywords: COVID-19; RT-PCR; SARS-CoV-2; chest; computed tomography; fecal swab; feces; nasopharyngeal swab; oropharyngeal swab; viral pneumonia.
. 2021 Mar 20;57(3):290.
doi: 10.3390/medicina57030290.
SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples
Barbara Brogna[SUP] 1 [/SUP], Carlo Brogna[SUP] 2 [/SUP], Mauro Petrillo[SUP] 3 [/SUP], Adriana Modestina Conte[SUP] 4 [/SUP], Giulio Benincasa[SUP] 5 [/SUP], Luigi Montano[SUP] 6 [/SUP], Marina Piscopo[SUP] 7 [/SUP]
Affiliations
- PMID: 33804646
- DOI: 10.3390/medicina57030290
Abstract
Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests' results on samples from the upper respiratory tract.
Keywords: COVID-19; RT-PCR; SARS-CoV-2; chest; computed tomography; fecal swab; feces; nasopharyngeal swab; oropharyngeal swab; viral pneumonia.