tetano
Editor, Senior Moderator
Medicine (Baltimore)
. 2022 Jan 21;101(3):e28639.
doi: 10.1097/MD.0000000000028639.
Clinical characteristics and outcomes of post-COVID-19 pulmonary fibrosis: A case-control study
Shereen Farghaly[SUP] 1 [/SUP], Mohammed Badedi[SUP] 2 [/SUP], Rehab Ibrahim[SUP] 1 [/SUP], Murad H Sadhan[SUP] 3 [/SUP], Aymn Alamoudi[SUP] 4 [/SUP], Awaji Alnami[SUP] 2 [/SUP], Abdulrahman Muhajir[SUP] 2 [/SUP]
Affiliations
Abstract
The development of pulmonary fibrosis is a rare complication of the novel coronavirus disease 2019 (COVID-19). Limited information is available in the literature about that, and the present study aimed to address this gap.This case-control study included 64 patients with post-COVID-19 pulmonary fibrosis who were hospitalized for COVID-19.The percentage of patients aged ≥65 years (44%) who demised was higher than those who survived (25%). Male patients (62%) had higher mortality than female patients (37%). The most frequently reported clinical symptoms were shortness of breath (98%), cough (91%), and fever (70%). Most COVID-19 patients with pulmonary fibrosis (81%) were admitted to an intensive care unit (ICU), and 63% required mechanical ventilation. Bilateral lung infiltrates (94%), "ground glass" opacity (91%), "honeycomb" lung (25%), and pulmonary consolidation (9%) were commonly identified in COVID-19 patients with pulmonary fibrosis who survived. The findings for computed tomography and dyspnea scale were significantly higher in severe cases admitted to the ICU who required mechanical ventilation. A higher computerized tomography score also correlated significantly with a longer duration of stay in hospital and a higher degree of dyspnea. Half of the COVID-19 patients with pulmonary fibrosis (50%) who survived required oxygen therapy, and those with "honeycomb" lung required long-term oxygen therapy to a far greater extent than others. Cox regression revealed that smoking and asthma were significantly associated with ICU admission and the risk of mortality.Post-COVID-19 pulmonary fibrosis is a severe complication that leads to permanent lung damage or death.
. 2022 Jan 21;101(3):e28639.
doi: 10.1097/MD.0000000000028639.
Clinical characteristics and outcomes of post-COVID-19 pulmonary fibrosis: A case-control study
Shereen Farghaly[SUP] 1 [/SUP], Mohammed Badedi[SUP] 2 [/SUP], Rehab Ibrahim[SUP] 1 [/SUP], Murad H Sadhan[SUP] 3 [/SUP], Aymn Alamoudi[SUP] 4 [/SUP], Awaji Alnami[SUP] 2 [/SUP], Abdulrahman Muhajir[SUP] 2 [/SUP]
Affiliations
- PMID: 35060549
- DOI: 10.1097/MD.0000000000028639
Abstract
The development of pulmonary fibrosis is a rare complication of the novel coronavirus disease 2019 (COVID-19). Limited information is available in the literature about that, and the present study aimed to address this gap.This case-control study included 64 patients with post-COVID-19 pulmonary fibrosis who were hospitalized for COVID-19.The percentage of patients aged ≥65 years (44%) who demised was higher than those who survived (25%). Male patients (62%) had higher mortality than female patients (37%). The most frequently reported clinical symptoms were shortness of breath (98%), cough (91%), and fever (70%). Most COVID-19 patients with pulmonary fibrosis (81%) were admitted to an intensive care unit (ICU), and 63% required mechanical ventilation. Bilateral lung infiltrates (94%), "ground glass" opacity (91%), "honeycomb" lung (25%), and pulmonary consolidation (9%) were commonly identified in COVID-19 patients with pulmonary fibrosis who survived. The findings for computed tomography and dyspnea scale were significantly higher in severe cases admitted to the ICU who required mechanical ventilation. A higher computerized tomography score also correlated significantly with a longer duration of stay in hospital and a higher degree of dyspnea. Half of the COVID-19 patients with pulmonary fibrosis (50%) who survived required oxygen therapy, and those with "honeycomb" lung required long-term oxygen therapy to a far greater extent than others. Cox regression revealed that smoking and asthma were significantly associated with ICU admission and the risk of mortality.Post-COVID-19 pulmonary fibrosis is a severe complication that leads to permanent lung damage or death.