tetano
Editor, Senior Moderator
Mediterr J Hematol Infect Dis
. 2021 Sep 1;13(1):e2021059.
doi: 10.4084/MJHID.2021.059. eCollection 2021.
Safety Warning for ChAdOx1 nCov-19 Vaccine in Patients with Sickle Cell Disease
S Alkindi[SUP] 1 [/SUP], R A Elsadek[SUP] 2 [/SUP], A V Pathare[SUP] 1 [/SUP]
Affiliations
Abstract
Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them had probably a fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.
Keywords: ChAdOx1 nCov-19 vaccine; SARS-CoV2; Sickle cell disease; Vaccine-induced immune thrombotic thrombocytopenia; Vaso-occlusive crisis.
. 2021 Sep 1;13(1):e2021059.
doi: 10.4084/MJHID.2021.059. eCollection 2021.
Safety Warning for ChAdOx1 nCov-19 Vaccine in Patients with Sickle Cell Disease
S Alkindi[SUP] 1 [/SUP], R A Elsadek[SUP] 2 [/SUP], A V Pathare[SUP] 1 [/SUP]
Affiliations
- PMID: 34527211
- PMCID: PMC8425344
- DOI: 10.4084/MJHID.2021.059
Abstract
Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them had probably a fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.
Keywords: ChAdOx1 nCov-19 vaccine; SARS-CoV2; Sickle cell disease; Vaccine-induced immune thrombotic thrombocytopenia; Vaso-occlusive crisis.