tetano
Editor, Senior Moderator
Immunity. 2018 Jan 16;48(1):174-184.e9. doi: 10.1016/j.immuni.2017.12.009.
[h=1]Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.[/h] McCarthy KR[SUP]1[/SUP], Watanabe A[SUP]2[/SUP], Kuraoka M[SUP]2[/SUP], Do KT[SUP]1[/SUP], McGee CE[SUP]3[/SUP], Sempowski GD[SUP]3[/SUP], Kepler TB[SUP]4[/SUP], Schmidt AG[SUP]1[/SUP], Kelsoe G[SUP]5[/SUP], Harrison SC[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human B cell antigen-receptor (BCR) repertoires reflect repeated exposures to evolving influenza viruses; new exposures update the previously generated B cell memory (Bmem) population. Despite structural similarity of hemagglutinins (HAs) from the two groups of influenza A viruses, cross-reacting antibodies (Abs) are uncommon. We analyzed Bmem compartments in three unrelated, adult donors and found frequent cross-group BCRs, both HA-head directed and non-head directed. Members of a clonal lineage from one donor had a BCR structure similar to that of a previously described Ab, encoded by different gene segments. Comparison showed that both Abs contacted the HA receptor-binding site through long heavy-chain third complementarity determining regions. Affinities of the clonal-lineage BCRs for historical influenza-virus HAs from both group 1 and group 2 viruses suggested that serial responses to seasonal influenza exposures had elicited the lineage and driven affinity maturation. We propose that appropriate immunization regimens might elicit a comparably broad response.
[h=4]KEYWORDS:[/h] B cell repertoire; clonal selection; convergent evolution; influenza hemagglutinin
PMID: 29343437 DOI: 10.1016/j.immuni.2017.12.009
[h=1]Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.[/h] McCarthy KR[SUP]1[/SUP], Watanabe A[SUP]2[/SUP], Kuraoka M[SUP]2[/SUP], Do KT[SUP]1[/SUP], McGee CE[SUP]3[/SUP], Sempowski GD[SUP]3[/SUP], Kepler TB[SUP]4[/SUP], Schmidt AG[SUP]1[/SUP], Kelsoe G[SUP]5[/SUP], Harrison SC[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human B cell antigen-receptor (BCR) repertoires reflect repeated exposures to evolving influenza viruses; new exposures update the previously generated B cell memory (Bmem) population. Despite structural similarity of hemagglutinins (HAs) from the two groups of influenza A viruses, cross-reacting antibodies (Abs) are uncommon. We analyzed Bmem compartments in three unrelated, adult donors and found frequent cross-group BCRs, both HA-head directed and non-head directed. Members of a clonal lineage from one donor had a BCR structure similar to that of a previously described Ab, encoded by different gene segments. Comparison showed that both Abs contacted the HA receptor-binding site through long heavy-chain third complementarity determining regions. Affinities of the clonal-lineage BCRs for historical influenza-virus HAs from both group 1 and group 2 viruses suggested that serial responses to seasonal influenza exposures had elicited the lineage and driven affinity maturation. We propose that appropriate immunization regimens might elicit a comparably broad response.
[h=4]KEYWORDS:[/h] B cell repertoire; clonal selection; convergent evolution; influenza hemagglutinin
PMID: 29343437 DOI: 10.1016/j.immuni.2017.12.009