tetano
Editor, Senior Moderator
Eur J Immunol. 2018 Dec 12. doi: 10.1002/eji.201847852. [Epub ahead of print]
[h=1]Memory CD4[SUP]+[/SUP] T cells enhance B cell responses to drifting influenza immunization.[/h] Gage E[SUP]1,[/SUP][SUP]2[/SUP], Van Hoeven N[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Cauwelaert ND[SUP]1[/SUP], Larsen SE[SUP]1[/SUP], Erasmus J[SUP]1[/SUP], Orr MT[SUP]1,[/SUP][SUP]2[/SUP], Coler RN[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A annually infects 5-10% of the world's human population resulting in one million deaths. Influenza causes annual epidemics and re-infects previously exposed individuals because of antigenic drift in the glycoprotein hemagglutinin. Due to antigenic drift, the immune system is simultaneously exposed to novel and conserved parts of the influenza virus via vaccination and/or infection throughout life. Preexisting immunity has long been known to augment subsequent hemagglutination inhibitory antibody (hAb) responses. However, the preexisting immunological contributors that influence hAb responses are not understood. Therefore, we adapted and developed sequential infection and immunization mouse models using drifted influenza strains to show that MHC Class II haplotype and T cell reactivity influences subsequent hAb responses. We found that CB6F1 mice infected with A/CA followed by immunization with A/PR8 have increased hAb responses to A/PR8 compared to C57BL/6 mice. Increased hAb responses in CB6F1 mice were CD4[SUP]+[/SUP] T cell and B cell dependent and corresponded to increased germinal center A/PR8-specific B and T follicular helper cells. These results suggest conserved MHC Class II restricted epitopes within HA are essential for B cells to respond to drifting influenza and could be leveraged to boost hAb responses. This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; infectious diseases; preexisting immunity; vaccinology
PMID: 30548475 DOI: 10.1002/eji.201847852
[h=1]Memory CD4[SUP]+[/SUP] T cells enhance B cell responses to drifting influenza immunization.[/h] Gage E[SUP]1,[/SUP][SUP]2[/SUP], Van Hoeven N[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Cauwelaert ND[SUP]1[/SUP], Larsen SE[SUP]1[/SUP], Erasmus J[SUP]1[/SUP], Orr MT[SUP]1,[/SUP][SUP]2[/SUP], Coler RN[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A annually infects 5-10% of the world's human population resulting in one million deaths. Influenza causes annual epidemics and re-infects previously exposed individuals because of antigenic drift in the glycoprotein hemagglutinin. Due to antigenic drift, the immune system is simultaneously exposed to novel and conserved parts of the influenza virus via vaccination and/or infection throughout life. Preexisting immunity has long been known to augment subsequent hemagglutination inhibitory antibody (hAb) responses. However, the preexisting immunological contributors that influence hAb responses are not understood. Therefore, we adapted and developed sequential infection and immunization mouse models using drifted influenza strains to show that MHC Class II haplotype and T cell reactivity influences subsequent hAb responses. We found that CB6F1 mice infected with A/CA followed by immunization with A/PR8 have increased hAb responses to A/PR8 compared to C57BL/6 mice. Increased hAb responses in CB6F1 mice were CD4[SUP]+[/SUP] T cell and B cell dependent and corresponded to increased germinal center A/PR8-specific B and T follicular helper cells. These results suggest conserved MHC Class II restricted epitopes within HA are essential for B cells to respond to drifting influenza and could be leveraged to boost hAb responses. This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; infectious diseases; preexisting immunity; vaccinology
PMID: 30548475 DOI: 10.1002/eji.201847852