tetano
Editor, Senior Moderator
Microb Pathog
. 2021 Mar 7;104836.
doi: 10.1016/j.micpath.2021.104836. Online ahead of print.
Contribution of STAT3 to the pathogenesis of COVID-19
Abdollah Jafarzadeh[SUP] 1 [/SUP], Maryam Nemati[SUP] 2 [/SUP], Sara Jafarzadeh[SUP] 3 [/SUP]
Affiliations
Abstract
Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine storm, large viral replication and massive cell death play fundamental roles in the pathogenesis of COVID-19. Extreme production of many kinds of pro-inflammatory cytokines and chemokines occur in severe COVID-19 that called cytokine storm. Signal transducer and activator of transcription-3 (STAT-3) present in the cytoplasm in an inactive form and can be stimulated by a vast range of cytokines, chemokines and growth factors. Thus, STAT-3 can participate in the induction of inflammatory responses during coronavirus infections. STAT-3 can also suppress anti-virus interferon response and induce unbalanced anti-virus adaptive immune response, through influencing Th17-, Th1-, Treg-, and B cell-mediated functions. Furthermore, STAT-3 can contribute to the M2 macrophage polarization, lung fibrosis and thrombosis. Moreover, STAT-3 may be directly targeted by some virus-derived protein and operate as a pro-viral or anti-viral element in a virus-specific process. Here, the possible contribution of STAT-3 to the pathogenesis of COVID-19 was explained, while providing potential approaches to target this transcription factor in an attempt for COVID-19 treatment.
Keywords: COVID-19; Immune response; Inflammation; Pathogenesis; SARS-CoV-2; STAT3; Treatment.
. 2021 Mar 7;104836.
doi: 10.1016/j.micpath.2021.104836. Online ahead of print.
Contribution of STAT3 to the pathogenesis of COVID-19
Abdollah Jafarzadeh[SUP] 1 [/SUP], Maryam Nemati[SUP] 2 [/SUP], Sara Jafarzadeh[SUP] 3 [/SUP]
Affiliations
- PMID: 33691172
- DOI: 10.1016/j.micpath.2021.104836
Abstract
Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine storm, large viral replication and massive cell death play fundamental roles in the pathogenesis of COVID-19. Extreme production of many kinds of pro-inflammatory cytokines and chemokines occur in severe COVID-19 that called cytokine storm. Signal transducer and activator of transcription-3 (STAT-3) present in the cytoplasm in an inactive form and can be stimulated by a vast range of cytokines, chemokines and growth factors. Thus, STAT-3 can participate in the induction of inflammatory responses during coronavirus infections. STAT-3 can also suppress anti-virus interferon response and induce unbalanced anti-virus adaptive immune response, through influencing Th17-, Th1-, Treg-, and B cell-mediated functions. Furthermore, STAT-3 can contribute to the M2 macrophage polarization, lung fibrosis and thrombosis. Moreover, STAT-3 may be directly targeted by some virus-derived protein and operate as a pro-viral or anti-viral element in a virus-specific process. Here, the possible contribution of STAT-3 to the pathogenesis of COVID-19 was explained, while providing potential approaches to target this transcription factor in an attempt for COVID-19 treatment.
Keywords: COVID-19; Immune response; Inflammation; Pathogenesis; SARS-CoV-2; STAT3; Treatment.