tetano
Editor, Senior Moderator
FEBS Lett. 2014 Dec 23. pii: S0014-5793(14)00899-0. doi: 10.1016/j.febslet.2014.12.019. [Epub ahead of print]
[h=1]MicroRNAs in the immune organs of chickens and ducks indicate divergence of immunity against H5N1 avian influenza.[/h] Li Z[SUP]1[/SUP], Zhang J[SUP]1[/SUP], Su J[SUP]2[/SUP], Liu Y[SUP]1[/SUP], Guo J[SUP]1[/SUP], Zhang Y[SUP]1[/SUP], Lu C[SUP]3[/SUP], Xing S[SUP]1[/SUP], Guan Y[SUP]4[/SUP], Li Y[SUP]4[/SUP], Sun B[SUP]5[/SUP], Zhao Z[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Chickens are susceptible to the highly pathogenic H5N1 strain of avian influenza virus (HPAIV), whereas ducks are not. Here, we used high-throughput sequencing to analyse the microRNA expression in the spleen, thymus and bursa of Fabricius of H5N1-HPAIV-infected and non-infected chickens and ducks. We annotated the genomic positions of duck microRNAs and we compared the microRNA repertoires of chickens and ducks. Our results showed that the microRNA expression patterns in the homologous immune organs of specific-pathogen-free (SPF) chickens and ducks diverge substantially. Moreover, there was larger divergence between the microRNA expression patterns in immune organs of HPAIV-infected chickens and HPAIV-infected ducks. Together, our results might help to elucidate the roles of microRNAs in the divergent immunity of chickens and ducks against H5N1-HPAIV.
Copyright ? 2014. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Chicken; Duck; Highly pathogenic H5N1 avian influenza; Immune organ; MicroRNA
PMID: 25541489 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25541489
[h=1]MicroRNAs in the immune organs of chickens and ducks indicate divergence of immunity against H5N1 avian influenza.[/h] Li Z[SUP]1[/SUP], Zhang J[SUP]1[/SUP], Su J[SUP]2[/SUP], Liu Y[SUP]1[/SUP], Guo J[SUP]1[/SUP], Zhang Y[SUP]1[/SUP], Lu C[SUP]3[/SUP], Xing S[SUP]1[/SUP], Guan Y[SUP]4[/SUP], Li Y[SUP]4[/SUP], Sun B[SUP]5[/SUP], Zhao Z[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Chickens are susceptible to the highly pathogenic H5N1 strain of avian influenza virus (HPAIV), whereas ducks are not. Here, we used high-throughput sequencing to analyse the microRNA expression in the spleen, thymus and bursa of Fabricius of H5N1-HPAIV-infected and non-infected chickens and ducks. We annotated the genomic positions of duck microRNAs and we compared the microRNA repertoires of chickens and ducks. Our results showed that the microRNA expression patterns in the homologous immune organs of specific-pathogen-free (SPF) chickens and ducks diverge substantially. Moreover, there was larger divergence between the microRNA expression patterns in immune organs of HPAIV-infected chickens and HPAIV-infected ducks. Together, our results might help to elucidate the roles of microRNAs in the divergent immunity of chickens and ducks against H5N1-HPAIV.
Copyright ? 2014. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Chicken; Duck; Highly pathogenic H5N1 avian influenza; Immune organ; MicroRNA
PMID: 25541489 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25541489