tetano
Editor, Senior Moderator
Mil Med Res
. 2020 Jun 7;7(1):28.
doi: 10.1186/s40779-020-00256-6.
Pattern of Liver Injury in Adult Patients With COVID-19: A Retrospective Analysis of 105 Patients
Qi Wang[SUP] 1 2 [/SUP], Hong Zhao[SUP] 1 [/SUP], Li-Gai Liu[SUP] 1 [/SUP], Yan-Bin Wang[SUP] 1 [/SUP], Ting Zhang[SUP] 1 [/SUP], Ming-Hui Li[SUP] 1 [/SUP], Yan-Li Xu[SUP] 3 [/SUP], Gui-Ju Gao[SUP] 3 [/SUP], Hao-Feng Xiong[SUP] 4 [/SUP], Ying Fan[SUP] 1 [/SUP], Ying Cao[SUP] 1 [/SUP], Rui Ding[SUP] 1 [/SUP], Jing-Jing Wang[SUP] 1 [/SUP], Cheng Cheng[SUP] 1 [/SUP], Wen Xie[SUP] 5 [/SUP]
Affiliations
Abstract
Background: Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) have been shown.
Methods: This is a single-center retrospective study. A total of 105 adult patients hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, and March 17, 2020 were included, and divided into mild group (n = 79) and severe group(n = 26). We compared liver functional test results between the two groups. Category of ALT change during the disease course was also examined.
Results: 56.2% (59/105) of the patients had unnormal ALT, AST, or total TBil throughout the course of the disease, but in 91.4% (96/105) cases the level of ALT, AST or TBil ≤3 fold of the upper limit of normal reference range (ULN). The overall distribution of ALT, AST, and TBil were all significantly difference between mild and severe group (P < 0.05). The percentage of the patients with elevated both ALT and AST was 12.7% (10/79) in mild cases vs. 46.2% (12/26) in severe cases (P = 0.001). 34.6% (9/26) severe group patients started to have abnormal ALT after admission, and 73.3% (77/105) of all patients had normal ALT before discharge.
Conclusions: Elevated liver function index is very common in patients with COVID-19 infection, and the level were less than 3 ? ULN, but most are reversible. The abnormality of 2 or more indexes is low in the patients with COVID-19, but it is more likely to occur in the severe group.
Keywords: Coronavirus disease-2019; Dynamic change; Liver function.
. 2020 Jun 7;7(1):28.
doi: 10.1186/s40779-020-00256-6.
Pattern of Liver Injury in Adult Patients With COVID-19: A Retrospective Analysis of 105 Patients
Qi Wang[SUP] 1 2 [/SUP], Hong Zhao[SUP] 1 [/SUP], Li-Gai Liu[SUP] 1 [/SUP], Yan-Bin Wang[SUP] 1 [/SUP], Ting Zhang[SUP] 1 [/SUP], Ming-Hui Li[SUP] 1 [/SUP], Yan-Li Xu[SUP] 3 [/SUP], Gui-Ju Gao[SUP] 3 [/SUP], Hao-Feng Xiong[SUP] 4 [/SUP], Ying Fan[SUP] 1 [/SUP], Ying Cao[SUP] 1 [/SUP], Rui Ding[SUP] 1 [/SUP], Jing-Jing Wang[SUP] 1 [/SUP], Cheng Cheng[SUP] 1 [/SUP], Wen Xie[SUP] 5 [/SUP]
Affiliations
- PMID: 32507110
- DOI: 10.1186/s40779-020-00256-6
Abstract
Background: Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) have been shown.
Methods: This is a single-center retrospective study. A total of 105 adult patients hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, and March 17, 2020 were included, and divided into mild group (n = 79) and severe group(n = 26). We compared liver functional test results between the two groups. Category of ALT change during the disease course was also examined.
Results: 56.2% (59/105) of the patients had unnormal ALT, AST, or total TBil throughout the course of the disease, but in 91.4% (96/105) cases the level of ALT, AST or TBil ≤3 fold of the upper limit of normal reference range (ULN). The overall distribution of ALT, AST, and TBil were all significantly difference between mild and severe group (P < 0.05). The percentage of the patients with elevated both ALT and AST was 12.7% (10/79) in mild cases vs. 46.2% (12/26) in severe cases (P = 0.001). 34.6% (9/26) severe group patients started to have abnormal ALT after admission, and 73.3% (77/105) of all patients had normal ALT before discharge.
Conclusions: Elevated liver function index is very common in patients with COVID-19 infection, and the level were less than 3 ? ULN, but most are reversible. The abnormality of 2 or more indexes is low in the patients with COVID-19, but it is more likely to occur in the severe group.
Keywords: Coronavirus disease-2019; Dynamic change; Liver function.