tetano
Editor, Senior Moderator
Angew Chem Int Ed Engl. 2017 Jul 18. doi: 10.1002/anie.201705769. [Epub ahead of print]
[h=1]Mineralized State of the Avian Influenza Virus in the Environment.[/h] Zhou H, Wang G, Wang X, Song Z, Tang R[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Although the circulation of avian influenza in humans is limited, they can be transmitted from Aves to humans, representing a great challenge. Herein, we suggest that influenza viruses from Aves might exist in a mineralized state due to the high calcium concentrations in the avian intestine. Using two typical influenza viruses as examples, we demonstrate these viruses can self-mineralize in simulated avian intestinal fluid, resulting in egg-like virus-mineral structured composites. The mineralized viruses are more robust, with enhanced infectivity and thermostability. More importantly, the mineral exterior of mineralized viruses can alter their cell internalization, expanding the possible tropisms. The discovery of a mineralized state of influenza highlights the integration of nanomaterials and viruses in the environment, which provides a new understanding of avian influenza infection and its control.
? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
[h=4]KEYWORDS:[/h] biomineralization; calcium phosphate; composite; simulated avian intestinal fluid; virus
PMID: 28722241 DOI: 10.1002/anie.201705769
[h=1]Mineralized State of the Avian Influenza Virus in the Environment.[/h] Zhou H, Wang G, Wang X, Song Z, Tang R[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Although the circulation of avian influenza in humans is limited, they can be transmitted from Aves to humans, representing a great challenge. Herein, we suggest that influenza viruses from Aves might exist in a mineralized state due to the high calcium concentrations in the avian intestine. Using two typical influenza viruses as examples, we demonstrate these viruses can self-mineralize in simulated avian intestinal fluid, resulting in egg-like virus-mineral structured composites. The mineralized viruses are more robust, with enhanced infectivity and thermostability. More importantly, the mineral exterior of mineralized viruses can alter their cell internalization, expanding the possible tropisms. The discovery of a mineralized state of influenza highlights the integration of nanomaterials and viruses in the environment, which provides a new understanding of avian influenza infection and its control.
? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
[h=4]KEYWORDS:[/h] biomineralization; calcium phosphate; composite; simulated avian intestinal fluid; virus
PMID: 28722241 DOI: 10.1002/anie.201705769