tetano
Editor, Senior Moderator
Mini Rev Med Chem
. 2022 Jan 28.
doi: 10.2174/1389557522999220128150814. Online ahead of print.
Interleukin Receptor Antagonists and Janus Kinase Inhibitors Repurposed for Treatment of COVID-19
Nitin Tandon[SUP] 1 [/SUP], Vijay Luxami[SUP] 2 [/SUP], Runjhun Tandon[SUP] 1 [/SUP], Kamaldeep Paul[SUP] 2 [/SUP]
Affiliations
Abstract
SARS-CoV-2 infection is the most contagious among the three coronavirus infections the world has witnessed to date which has affected almost all parts of the world in millions of population since its outbreak in china in Dec. 2019. Moreover, it has severely hit the world economy and therefore there is a dire need to develop the treatment of this deadly disease. The numbers of potential vaccines are in the early or advanced stage of clinical trials. But the development of a vaccine is a very tedious and time-consuming task. Therefore, various groups are working on the repurposing of drugs with already known safety and efficacy profiles to shorten the time of development of the potential treatment. The main aim of this review article is to summarize the clinical outcomes of Interleukin receptor antagonists and Janus kinase inhibitors based drugs which have been repurposed for the treatment of COVID-19 associated with SARS-CoV-2.
Keywords: COVID-19; Interleukin receptor antagonists; Janus kinase inhibitors; SARS-CoV-2; clinical outcomes; the standard of care.
. 2022 Jan 28.
doi: 10.2174/1389557522999220128150814. Online ahead of print.
Interleukin Receptor Antagonists and Janus Kinase Inhibitors Repurposed for Treatment of COVID-19
Nitin Tandon[SUP] 1 [/SUP], Vijay Luxami[SUP] 2 [/SUP], Runjhun Tandon[SUP] 1 [/SUP], Kamaldeep Paul[SUP] 2 [/SUP]
Affiliations
- PMID: 35088667
- DOI: 10.2174/1389557522999220128150814
Abstract
SARS-CoV-2 infection is the most contagious among the three coronavirus infections the world has witnessed to date which has affected almost all parts of the world in millions of population since its outbreak in china in Dec. 2019. Moreover, it has severely hit the world economy and therefore there is a dire need to develop the treatment of this deadly disease. The numbers of potential vaccines are in the early or advanced stage of clinical trials. But the development of a vaccine is a very tedious and time-consuming task. Therefore, various groups are working on the repurposing of drugs with already known safety and efficacy profiles to shorten the time of development of the potential treatment. The main aim of this review article is to summarize the clinical outcomes of Interleukin receptor antagonists and Janus kinase inhibitors based drugs which have been repurposed for the treatment of COVID-19 associated with SARS-CoV-2.
Keywords: COVID-19; Interleukin receptor antagonists; Janus kinase inhibitors; SARS-CoV-2; clinical outcomes; the standard of care.