tetano
Editor, Senior Moderator
J Theor Biol. 2016 Nov 14. pii: S0022-5193(16)30362-9. doi: 10.1016/j.jtbi.2016.11.008. [Epub ahead of print]
[h=1]Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host.[/h] Yan AW[SUP]1[/SUP], Cao P[SUP]1[/SUP], Heffernan JM[SUP]2[/SUP], McVernon J[SUP]3[/SUP], Quinn KM[SUP]4[/SUP], La Gruta NL[SUP]4[/SUP], Laurie KL[SUP]5[/SUP], McCaw JM[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model explains the experimentally observed shortening of a second infection when cross-reactivity is present, and shows that memory in the cellular adaptive immune response is necessary to protect against a second infection.
Copyright ? 2016 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Cytotoxic T lymphocyte; Immunology; Mathematical model; Viral dynamics
PMID: 27856216 DOI: 10.1016/j.jtbi.2016.11.008
[PubMed - as supplied by publisher]
[h=1]Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host.[/h] Yan AW[SUP]1[/SUP], Cao P[SUP]1[/SUP], Heffernan JM[SUP]2[/SUP], McVernon J[SUP]3[/SUP], Quinn KM[SUP]4[/SUP], La Gruta NL[SUP]4[/SUP], Laurie KL[SUP]5[/SUP], McCaw JM[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model explains the experimentally observed shortening of a second infection when cross-reactivity is present, and shows that memory in the cellular adaptive immune response is necessary to protect against a second infection.
Copyright ? 2016 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Cytotoxic T lymphocyte; Immunology; Mathematical model; Viral dynamics
PMID: 27856216 DOI: 10.1016/j.jtbi.2016.11.008
[PubMed - as supplied by publisher]