tetano
Editor, Senior Moderator
Mol Biol Rep
. 2022 Mar 6.
doi: 10.1007/s11033-022-07308-1. Online ahead of print.
Association of severity and mortality of Covid-19 cases among acute kidney injury and sexual dimorphism
Mukul Kumar Singh[SUP] #[/SUP][SUP] 1 [/SUP], Mayank Jain[SUP] #[/SUP][SUP] 2 [/SUP], Hari Shyam[SUP] #[/SUP][SUP] 2 [/SUP], Dinesh Kumar Sahu[SUP] #[/SUP][SUP] 3 [/SUP], Archana Mishra[SUP] 2 [/SUP], Pratap Shankar[SUP] 4 [/SUP], Shailendra Kumar[SUP] 2 [/SUP], Vishwajeet Singh[SUP] 5 [/SUP]
Affiliations
Abstract
Introduction: The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.
Material and methods: The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates the viral genome protein interactions and initiates the predictive multiorgan failure followed by acute kidney injury (AKI) in Covid-19 infected male population.
Conclusion: Besides, the knowledge and lessons learned from the study depict that cellular and molecular links may explain the risk and severity of Covid-19 and AKI in the male population and lead to management of Covid-19 induced AKI. Therefore, this review explored the pathways associated with the pathogenesis of two diseased conditions with sex disparity.
Keywords: AKI; Covid-19; Immunosuppression; Pathogenesis; Sex-disparity.
. 2022 Mar 6.
doi: 10.1007/s11033-022-07308-1. Online ahead of print.
Association of severity and mortality of Covid-19 cases among acute kidney injury and sexual dimorphism
Mukul Kumar Singh[SUP] #[/SUP][SUP] 1 [/SUP], Mayank Jain[SUP] #[/SUP][SUP] 2 [/SUP], Hari Shyam[SUP] #[/SUP][SUP] 2 [/SUP], Dinesh Kumar Sahu[SUP] #[/SUP][SUP] 3 [/SUP], Archana Mishra[SUP] 2 [/SUP], Pratap Shankar[SUP] 4 [/SUP], Shailendra Kumar[SUP] 2 [/SUP], Vishwajeet Singh[SUP] 5 [/SUP]
Affiliations
- PMID: 35249167
- DOI: 10.1007/s11033-022-07308-1
Abstract
Introduction: The outbreak of coronavirus disease 2019 (Covid-19) severely impacted global health and economic status. The native receptor-ligand interaction of Angiotensin-converting enzyme 2 (ACE2) and S protein induces host cell pathogenesis via immunosuppression.
Material and methods: The emerging evidence reports the sex disparity in Covid-19 induced mortality rate which affects abundantly men population. Although the biological interaction of Covid-19 with receptor upregulates the viral genome protein interactions and initiates the predictive multiorgan failure followed by acute kidney injury (AKI) in Covid-19 infected male population.
Conclusion: Besides, the knowledge and lessons learned from the study depict that cellular and molecular links may explain the risk and severity of Covid-19 and AKI in the male population and lead to management of Covid-19 induced AKI. Therefore, this review explored the pathways associated with the pathogenesis of two diseased conditions with sex disparity.
Keywords: AKI; Covid-19; Immunosuppression; Pathogenesis; Sex-disparity.