tetano
Editor, Senior Moderator
Mol Biol Rep
. 2023 Jan 28.
doi: 10.1007/s11033-023-08244-4. Online ahead of print.
Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection
Murat Acat[SUP] 1 [/SUP], Pınar Yıldız Gülhan[SUP] 2 [/SUP], Recep Eröz[SUP] 3 [/SUP], Ayşegül Ertınmaz Özkan[SUP] 4 [/SUP], Oğuzhan Koca[SUP] 5 [/SUP], Caner Çınar[SUP] 6 [/SUP]
Affiliations
Abstract
Aim: The current study aimed to evaluate the effects of caspase-8 (CASP8) and mitogen-activated protein kinase 1 (MAPK1) gene expression levels and their products on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: A total of 40 patients (men, 15 [37.5%]; women, 25 [62.5%]) with COVID-19 infection were included in the current study. The patients were divided into four main groups based on disease severity: mild (n = 7), moderate (n = 10), severe (n = 14), and critical (n = 9). Individuals aged < 18 years and pregnant women were excluded. Patients were classified according to the World Health Organization (WHO) classification system (WHO/2019-nCoV/clinical/2021.1).
Results: Considering all groups, statistically significant differences were detected among all groups for both CASP8[SUP]2-ΔΔCt[/SUP] (p = 0.006) and MAPK1 2[SUP]-ΔΔCt[/SUP] values (p = 0.015). Moreover, statistically significant differences were detected between mild and moderate (p = 0.013), moderate and critical (p = 0.018), and severe and critical (p = 0.023) groups for lymphocytes.
Conclusion: The CASP8/MAPK1 expression levels and/or its products are essential in preventing injury caused by COVID-19 infection. They play crucial roles in maintaining cellular homeostasis and viability. Furthermore, CASP8/MAPK1 levels can provide information about disease severity.
Keywords: CASP8 gene; Cellular homeostasis; MAPK1; SARS-CoV-2.
. 2023 Jan 28.
doi: 10.1007/s11033-023-08244-4. Online ahead of print.
Evaluation of both expression and serum protein levels of caspase-8 and mitogen-activated protein kinase 1 genes in patients with different severities of COVID-19 infection
Murat Acat[SUP] 1 [/SUP], Pınar Yıldız Gülhan[SUP] 2 [/SUP], Recep Eröz[SUP] 3 [/SUP], Ayşegül Ertınmaz Özkan[SUP] 4 [/SUP], Oğuzhan Koca[SUP] 5 [/SUP], Caner Çınar[SUP] 6 [/SUP]
Affiliations
- PMID: 36708447
- DOI: 10.1007/s11033-023-08244-4
Abstract
Aim: The current study aimed to evaluate the effects of caspase-8 (CASP8) and mitogen-activated protein kinase 1 (MAPK1) gene expression levels and their products on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: A total of 40 patients (men, 15 [37.5%]; women, 25 [62.5%]) with COVID-19 infection were included in the current study. The patients were divided into four main groups based on disease severity: mild (n = 7), moderate (n = 10), severe (n = 14), and critical (n = 9). Individuals aged < 18 years and pregnant women were excluded. Patients were classified according to the World Health Organization (WHO) classification system (WHO/2019-nCoV/clinical/2021.1).
Results: Considering all groups, statistically significant differences were detected among all groups for both CASP8[SUP]2-ΔΔCt[/SUP] (p = 0.006) and MAPK1 2[SUP]-ΔΔCt[/SUP] values (p = 0.015). Moreover, statistically significant differences were detected between mild and moderate (p = 0.013), moderate and critical (p = 0.018), and severe and critical (p = 0.023) groups for lymphocytes.
Conclusion: The CASP8/MAPK1 expression levels and/or its products are essential in preventing injury caused by COVID-19 infection. They play crucial roles in maintaining cellular homeostasis and viability. Furthermore, CASP8/MAPK1 levels can provide information about disease severity.
Keywords: CASP8 gene; Cellular homeostasis; MAPK1; SARS-CoV-2.