tetano
Editor, Senior Moderator
Mol Biol Rep
. 2023 Sep 23.
doi: 10.1007/s11033-023-08785-8. Online ahead of print. Stem cell-derived organoid models for SARS-CoV-2 and its molecular interaction with host cells
Ladan Dawoody Nejad[SUP] 1 2 3 [/SUP], Lisa Marie Julian[SUP] 4 5 [/SUP]
Affiliations
Modeling severe acute respiratory syndrome, Coronavirus 2 (SARS-CoV-2) infection in stem cell-derived organoids has helped in our understanding of the molecular pathogenesis of COVID-19 disease due to their resemblance to actual human tissues or organs. Over the past decade, organoid 3-dimensional (3D) cultures have represented a new perspective and considerable advancement over traditional in vitro 2-dimensional (2D) cell cultures. COVID-19 disease causes lung injury and multi-organ failure leading to death, especially in older patients. There is an urgent need for physiological models to study SARS-CoV-2 infection during the pandemic. Human stem cell-derived organoids can provide insight into understanding the SARS-CoV-2 cell entry molecular mechanism. Identifying such complexities will help to develop the best preventive drug targets.
Keywords: COVID-19; Cell entry mechanism; Organoids; SARS-CoV-2; Spikes.
. 2023 Sep 23.
doi: 10.1007/s11033-023-08785-8. Online ahead of print. Stem cell-derived organoid models for SARS-CoV-2 and its molecular interaction with host cells
Ladan Dawoody Nejad[SUP] 1 2 3 [/SUP], Lisa Marie Julian[SUP] 4 5 [/SUP]
Affiliations
- PMID: 37740859
- DOI: 10.1007/s11033-023-08785-8
Modeling severe acute respiratory syndrome, Coronavirus 2 (SARS-CoV-2) infection in stem cell-derived organoids has helped in our understanding of the molecular pathogenesis of COVID-19 disease due to their resemblance to actual human tissues or organs. Over the past decade, organoid 3-dimensional (3D) cultures have represented a new perspective and considerable advancement over traditional in vitro 2-dimensional (2D) cell cultures. COVID-19 disease causes lung injury and multi-organ failure leading to death, especially in older patients. There is an urgent need for physiological models to study SARS-CoV-2 infection during the pandemic. Human stem cell-derived organoids can provide insight into understanding the SARS-CoV-2 cell entry molecular mechanism. Identifying such complexities will help to develop the best preventive drug targets.
Keywords: COVID-19; Cell entry mechanism; Organoids; SARS-CoV-2; Spikes.