tetano
Editor, Senior Moderator
Mol Cell Biochem
. 2022 Feb 24.
doi: 10.1007/s11010-022-04393-5. Online ahead of print.
Identification of intrinsically disorder regions in non-structural proteins of SARS-CoV-2: New insights into drug and vaccine resistance
Farah Anjum[SUP] 1 [/SUP], Taj Mohammad[SUP] 2 [/SUP], Purva Asrani[SUP] 3 [/SUP], Alaa Shafie[SUP] 1 [/SUP], Shailza Singh[SUP] 4 [/SUP], Dharmendra Kumar Yadav[SUP] 5 [/SUP], Vladimir N Uversky[SUP] 6 [/SUP], Md Imtaiyaz Hassan[SUP] 7 [/SUP]
Affiliations
Abstract
The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 2019 and caused coronavirus disease 2019 (COVID-19), which causes pneumonia and severe acute respiratory distress syndrome. It is a highly infectious pathogen that promptly spread. Like other beta coronaviruses, SARS-CoV-2 encodes some non-structural proteins (NSPs), playing crucial roles in viral transcription and replication. NSPs likely have essential roles in viral pathogenesis by manipulating many cellular processes. We performed a sequence-based analysis of NSPs to get insights into their intrinsic disorders, and their functions in viral replication were annotated and discussed in detail. Here, we provide newer insights into the structurally disordered regions of SARS-CoV-2 NSPs. Our analysis reveals that the SARS-CoV-2 proteome has a chunk of the disordered region that might be responsible for increasing its virulence. In addition, mutations in these regions are presumably responsible for drug and vaccine resistance. These findings suggested that the structurally disordered regions of SARS-CoV-2 NSPs might be invulnerable in COVID-19.
Keywords: COVID-19; COVID-19 therapeutics; Intrinsically disordered proteins; Molecular pathogenesis; SARS-CoV-2; Vaccine development.
. 2022 Feb 24.
doi: 10.1007/s11010-022-04393-5. Online ahead of print.
Identification of intrinsically disorder regions in non-structural proteins of SARS-CoV-2: New insights into drug and vaccine resistance
Farah Anjum[SUP] 1 [/SUP], Taj Mohammad[SUP] 2 [/SUP], Purva Asrani[SUP] 3 [/SUP], Alaa Shafie[SUP] 1 [/SUP], Shailza Singh[SUP] 4 [/SUP], Dharmendra Kumar Yadav[SUP] 5 [/SUP], Vladimir N Uversky[SUP] 6 [/SUP], Md Imtaiyaz Hassan[SUP] 7 [/SUP]
Affiliations
- PMID: 35211823
- DOI: 10.1007/s11010-022-04393-5
Abstract
The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 2019 and caused coronavirus disease 2019 (COVID-19), which causes pneumonia and severe acute respiratory distress syndrome. It is a highly infectious pathogen that promptly spread. Like other beta coronaviruses, SARS-CoV-2 encodes some non-structural proteins (NSPs), playing crucial roles in viral transcription and replication. NSPs likely have essential roles in viral pathogenesis by manipulating many cellular processes. We performed a sequence-based analysis of NSPs to get insights into their intrinsic disorders, and their functions in viral replication were annotated and discussed in detail. Here, we provide newer insights into the structurally disordered regions of SARS-CoV-2 NSPs. Our analysis reveals that the SARS-CoV-2 proteome has a chunk of the disordered region that might be responsible for increasing its virulence. In addition, mutations in these regions are presumably responsible for drug and vaccine resistance. These findings suggested that the structurally disordered regions of SARS-CoV-2 NSPs might be invulnerable in COVID-19.
Keywords: COVID-19; COVID-19 therapeutics; Intrinsically disordered proteins; Molecular pathogenesis; SARS-CoV-2; Vaccine development.