tetano
Editor, Senior Moderator
Mol Cell Biochem
. 2022 Jan 23.
doi: 10.1007/s11010-021-04336-6. Online ahead of print.
Ocular transmissibility of COVID-19: possibilities and perspectives
Gavin Davis[SUP] 1 [/SUP], Kin Li[SUP] 1 [/SUP], Finosh G Thankam[SUP] 1 [/SUP], Daniel R Wilson[SUP] 1 [/SUP], Devendra K Agrawal[SUP] 2 [/SUP]
Affiliations
Abstract
Since the initial outbreak of coronavirus disease 2019 (COVID-19), extensive research has emerged from across the globe to understand the pathophysiology of this novel coronavirus. Transmission of this virus is a subject of particular interest as researchers work to understand which protective and preventative measures are most effective. Despite the well understood model of aerosol-respiratory mediated transmission, the exact mechanism underlying the inoculation, infection and spread of COVID-19 is currently unknown. Given anatomical positioning and near constant exposure to aerosolized pathogens, the eye may be a possible gateway for COVID-19 infection. This critical review explores the possibility of an ocular-systemic or ocular-nasal-pulmonic pathway of COVID-19 infection and includes novel insights into the possible immunological mechanisms leading to cytokine surge.
Keywords: ACE2; COVID-19; Eye; Nasolacrimal; Ocular infection.
. 2022 Jan 23.
doi: 10.1007/s11010-021-04336-6. Online ahead of print.
Ocular transmissibility of COVID-19: possibilities and perspectives
Gavin Davis[SUP] 1 [/SUP], Kin Li[SUP] 1 [/SUP], Finosh G Thankam[SUP] 1 [/SUP], Daniel R Wilson[SUP] 1 [/SUP], Devendra K Agrawal[SUP] 2 [/SUP]
Affiliations
- PMID: 35066705
- DOI: 10.1007/s11010-021-04336-6
Abstract
Since the initial outbreak of coronavirus disease 2019 (COVID-19), extensive research has emerged from across the globe to understand the pathophysiology of this novel coronavirus. Transmission of this virus is a subject of particular interest as researchers work to understand which protective and preventative measures are most effective. Despite the well understood model of aerosol-respiratory mediated transmission, the exact mechanism underlying the inoculation, infection and spread of COVID-19 is currently unknown. Given anatomical positioning and near constant exposure to aerosolized pathogens, the eye may be a possible gateway for COVID-19 infection. This critical review explores the possibility of an ocular-systemic or ocular-nasal-pulmonic pathway of COVID-19 infection and includes novel insights into the possible immunological mechanisms leading to cytokine surge.
Keywords: ACE2; COVID-19; Eye; Nasolacrimal; Ocular infection.