tetano
Editor, Senior Moderator
Mol Cells
. 2021 Jun 14.
doi: 10.14348/molcells.2021.0079. Online ahead of print.
Phenotypes and Functions of SARS-CoV-2-Reactive T Cells
Min Kyung Jung[SUP] 1 [/SUP], Eui-Cheol Shin[SUP] 1 2 [/SUP]
Affiliations
Abstract
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which is an ongoing pandemic disease. SARS-CoV-2- specific CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T-cell responses have been detected and characterized not only in COVID-19 patients and convalescents, but also unexposed individuals. Here, we review the phenotypes and functions of SARS-CoV-2-specific T cells in COVID-19 patients and the relationships between SARS-CoV-2-specific T-cell responses and COVID-19 severity. In addition, we describe the phenotypes and functions of SARS-CoV-2-specific memory T cells after recovery from COVID-19 and discuss the presence of SARS-CoV-2-reactive T cells in unexposed individuals and SARS-CoV-2-specific T-cell responses elicited by COVID-19 vaccines. A better understanding of T-cell responses is important for effective control of the current COVID-19 pandemic.
Keywords: COVID-19; SARS-CoV-2; T cell; vaccine.
. 2021 Jun 14.
doi: 10.14348/molcells.2021.0079. Online ahead of print.
Phenotypes and Functions of SARS-CoV-2-Reactive T Cells
Min Kyung Jung[SUP] 1 [/SUP], Eui-Cheol Shin[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34120892
- DOI: 10.14348/molcells.2021.0079
Abstract
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which is an ongoing pandemic disease. SARS-CoV-2- specific CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T-cell responses have been detected and characterized not only in COVID-19 patients and convalescents, but also unexposed individuals. Here, we review the phenotypes and functions of SARS-CoV-2-specific T cells in COVID-19 patients and the relationships between SARS-CoV-2-specific T-cell responses and COVID-19 severity. In addition, we describe the phenotypes and functions of SARS-CoV-2-specific memory T cells after recovery from COVID-19 and discuss the presence of SARS-CoV-2-reactive T cells in unexposed individuals and SARS-CoV-2-specific T-cell responses elicited by COVID-19 vaccines. A better understanding of T-cell responses is important for effective control of the current COVID-19 pandemic.
Keywords: COVID-19; SARS-CoV-2; T cell; vaccine.