tetano
Editor, Senior Moderator
Mol Inform
. 2021 Aug 10.
doi: 10.1002/minf.202100031. Online ahead of print.
ACE2-Variants Indicate Potential SARS-CoV-2-Susceptibility in Animals: A Molecular Dynamics Study
Szymon Pach[SUP] 1 [/SUP], Trung Ngoc Nguyen[SUP] 1 [/SUP], Jakob Trimpert[SUP] 2 [/SUP], Dusan Kunec[SUP] 2 [/SUP], Nikolaus Osterrieder[SUP] 2 3 [/SUP], Gerhard Wolber[SUP] 1 [/SUP]
Affiliations
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to be a global threat, causing millions of deaths worldwide. SARS-CoV-2 is an enveloped virus with spike (S) glycoproteins conferring binding to the host cell's angiotensin-converting enzyme 2 (ACE2), which is critical for cellular entry. The host range of the virus extends well beyond humans and non-human primates. Natural and experimental infections have confirmed the high susceptibility of cats, ferrets, and Syrian hamsters, whereas dogs, mice, rats, pigs, and chickens are refractory to SARS-CoV-2 infection. To investigate the underlying reason for the variable susceptibility observed in different species, we have developed molecular descriptors to efficiently analyse dynamic simulation models of complexes between SARS-CoV-2 S and ACE2. Our extensive analyses represent the first systematic structure-based approach that allows predictions of species susceptibility to SARS-CoV-2 infection.
Keywords: ACE2; Molecular dynamics; Molecular modeling; SARS-CoV-2; Spike.
. 2021 Aug 10.
doi: 10.1002/minf.202100031. Online ahead of print.
ACE2-Variants Indicate Potential SARS-CoV-2-Susceptibility in Animals: A Molecular Dynamics Study
Szymon Pach[SUP] 1 [/SUP], Trung Ngoc Nguyen[SUP] 1 [/SUP], Jakob Trimpert[SUP] 2 [/SUP], Dusan Kunec[SUP] 2 [/SUP], Nikolaus Osterrieder[SUP] 2 3 [/SUP], Gerhard Wolber[SUP] 1 [/SUP]
Affiliations
- PMID: 34378348
- DOI: 10.1002/minf.202100031
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to be a global threat, causing millions of deaths worldwide. SARS-CoV-2 is an enveloped virus with spike (S) glycoproteins conferring binding to the host cell's angiotensin-converting enzyme 2 (ACE2), which is critical for cellular entry. The host range of the virus extends well beyond humans and non-human primates. Natural and experimental infections have confirmed the high susceptibility of cats, ferrets, and Syrian hamsters, whereas dogs, mice, rats, pigs, and chickens are refractory to SARS-CoV-2 infection. To investigate the underlying reason for the variable susceptibility observed in different species, we have developed molecular descriptors to efficiently analyse dynamic simulation models of complexes between SARS-CoV-2 S and ACE2. Our extensive analyses represent the first systematic structure-based approach that allows predictions of species susceptibility to SARS-CoV-2 infection.
Keywords: ACE2; Molecular dynamics; Molecular modeling; SARS-CoV-2; Spike.