Molecular-biological and antigenic features of H5N1 subtype highly pathogenic influenza virus strains isolated in southern Siberia in 2005-2009

[tetano]

Zh Mikrobiol Epidemiol Immunobiol. 2011 Sep-Oct;(5):40-3.
[Molecular-biological and antigenic features of H5N1 subtype highly pathogenic influenza virus strains isolated in southern Siberia in 2005-2009].
[Article in Russian]
[No authors listed]
Abstract
AIM:

Study of molecular-biological and antigenic features of H5N1 subtype virus strains isolated in southern Siberia in 2005-2009.
MATERIALS AND METHODS:

Study was performed by using standard procedures according to WHO recommendations.
RESULTS:

Hemagglutinin gene of H5N1 subtype virus strain isolated in Siberia belongs to 2 genetical lineages: 2.2 and 2.3.2. Strains of these 2 lineages have antigenic differences. All of the strains are highly pathogenic for chicken and white mice.
CONCLUSION:

H5N1 subtype highly pathogenic influenza virus variants of 2 different antigenic lineages that have antigenic differences circulated in Siberia in 2005-2009. A possible role of antigenic drift in evolution of H5N1 subtype influenza virus is discussed.

PMID:
22145348
[PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/22145348