tetano
Editor, Senior Moderator
Infection, Genetics and Evolution
Available online 16 August 2012
In Press, Accepted Manuscript ? Note to users
Cover image
Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010?2011 epidemic season
I. Soboleva,
O. Kurskayaa,
I. Susloparova,
T. Ilyichevaa, b, Corresponding author contact information, E-mail the corresponding author,
A. Shestopalova
a State Research Center of Virology and Biotechnology ?Vector?, Koltsovo, Novosibirsk region, 630559, Russia
b Novosibirsk State University, Pirogov St., 2, Novosibirsk, 630090, Russia
Received 26 February 2012. Revised 15 July 2012. Accepted 23 July 2012. Available online 16 August 2012.
http://dx.doi.org/10.1016/j.meegid.2012.07.014,
Abstract
Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulating at the moment in Eurasia.
Highlights
► H3N2 virus strains circulating in 2009-2011 in Western Siberia were described. ► HA of strains of 2011 are similar to HA of A/Victoria/210/2009 and A/Hessen/5/2010. ► HA of strains of 2011 belong to 1 of 2 philogenetic group from A/Perth/16/2009 clade. ► Strains don?t contain specific amino-acid changes in NA protein causing reduction of sensitivity to NA inhibitors.
http://www.sciencedirect.com/science/article/pii/S156713481200247X
Available online 16 August 2012
In Press, Accepted Manuscript ? Note to users
Cover image
Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010?2011 epidemic season
I. Soboleva,
O. Kurskayaa,
I. Susloparova,
T. Ilyichevaa, b, Corresponding author contact information, E-mail the corresponding author,
A. Shestopalova
a State Research Center of Virology and Biotechnology ?Vector?, Koltsovo, Novosibirsk region, 630559, Russia
b Novosibirsk State University, Pirogov St., 2, Novosibirsk, 630090, Russia
Received 26 February 2012. Revised 15 July 2012. Accepted 23 July 2012. Available online 16 August 2012.
http://dx.doi.org/10.1016/j.meegid.2012.07.014,
Abstract
Molecular genetic and antigenic features of influenza A/H3N2 virus strains isolated in Western Siberia in 2011 are similar to those of the vaccine strain A/Perth/16/2009 despite a number of unique amino-acid changes. The strains lack specific amino-acid changes in NA protein providing decrease of sensibility to NA inhibitors activity that used in medical practice. Based on phylogenic analysis of HA protein amino-acid sequences examined strains are similar to influenza A/H3N2 virus strains circulating at the moment in Eurasia.
Highlights
► H3N2 virus strains circulating in 2009-2011 in Western Siberia were described. ► HA of strains of 2011 are similar to HA of A/Victoria/210/2009 and A/Hessen/5/2010. ► HA of strains of 2011 belong to 1 of 2 philogenetic group from A/Perth/16/2009 clade. ► Strains don?t contain specific amino-acid changes in NA protein causing reduction of sensitivity to NA inhibitors.
http://www.sciencedirect.com/science/article/pii/S156713481200247X