tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2018 Feb 28. doi: 10.1111/irv.12549. [Epub ahead of print]
[h=1]Molecular Genetic Characteristics of Influenza A Virus Clinically Isolated during 2011-2016 Influenza Seasons in Korea.[/h] Lee HS[SUP]1[/SUP], Noh JY[SUP]2[/SUP], Song JY[SUP]2[/SUP], Cheong HJ[SUP]2[/SUP], Choi WS[SUP]3[/SUP], Jeong HW[SUP]4[/SUP], Wie SH[SUP]5[/SUP], Kim WJ[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A viruses are classified under the Orthomyxoviridae family, and consist of several subtypes, based on their hemagglutinin (HA) and neuraminidase (NA) composition. In some cases, reassortment of the 8 viral RNA segments may occur if different influenza viruses infect the same host, thereby generating new viral strains (antigenic shift). Mutations in the genes of influenza A viruses are enhanced by the absence of RNA proofreading enzymes; in particular, substitutions in the HA protein alter the viral antigenic epitopes sufficiently to avoid the host immune response (antigenic drift). These antigenic changes can trigger the generation of new strains and subgroups, leading to pandemics or new epidemics worldwide [1-3]. This article is protected by copyright. All rights reserved.
PMID: 29489060 DOI: 10.1111/irv.12549
[h=1]Molecular Genetic Characteristics of Influenza A Virus Clinically Isolated during 2011-2016 Influenza Seasons in Korea.[/h] Lee HS[SUP]1[/SUP], Noh JY[SUP]2[/SUP], Song JY[SUP]2[/SUP], Cheong HJ[SUP]2[/SUP], Choi WS[SUP]3[/SUP], Jeong HW[SUP]4[/SUP], Wie SH[SUP]5[/SUP], Kim WJ[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A viruses are classified under the Orthomyxoviridae family, and consist of several subtypes, based on their hemagglutinin (HA) and neuraminidase (NA) composition. In some cases, reassortment of the 8 viral RNA segments may occur if different influenza viruses infect the same host, thereby generating new viral strains (antigenic shift). Mutations in the genes of influenza A viruses are enhanced by the absence of RNA proofreading enzymes; in particular, substitutions in the HA protein alter the viral antigenic epitopes sufficiently to avoid the host immune response (antigenic drift). These antigenic changes can trigger the generation of new strains and subgroups, leading to pandemics or new epidemics worldwide [1-3]. This article is protected by copyright. All rights reserved.
PMID: 29489060 DOI: 10.1111/irv.12549