tetano
Editor, Senior Moderator
Molecules
. 2020 Nov 24;25(23):E5496.
doi: 10.3390/molecules25235496.
Alkaloids: Therapeutic Potential against Human Coronaviruses
Burtram C Fielding[SUP] 1 [/SUP], Carlos da Silva Maia Bezerra Filho[SUP] 2 [/SUP], Nasser S M Ismail[SUP] 3 [/SUP], Dami?o Pergentino de Sousa[SUP] 2 [/SUP]
Affiliations
Abstract
Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2.
Keywords: COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; antiviral drug; coronaviruses; natural products; virus.
. 2020 Nov 24;25(23):E5496.
doi: 10.3390/molecules25235496.
Alkaloids: Therapeutic Potential against Human Coronaviruses
Burtram C Fielding[SUP] 1 [/SUP], Carlos da Silva Maia Bezerra Filho[SUP] 2 [/SUP], Nasser S M Ismail[SUP] 3 [/SUP], Dami?o Pergentino de Sousa[SUP] 2 [/SUP]
Affiliations
- PMID: 33255253
- DOI: 10.3390/molecules25235496
Abstract
Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential use as bioactive agents against SARS-CoV-2.
Keywords: COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; antiviral drug; coronaviruses; natural products; virus.