tetano
Editor, Senior Moderator
J Infect Dis. 2012 Jun 21. [Epub ahead of print]
MORTALITY ATTRIBUTABLE TO 9 COMMON INFECTIONS: significant effect of influenza A, RSV, influenza B, norovirus and parainfluenza in the elderly.
van Asten L, van den Wijngaard C, van Pelt W, van de Kassteele J, Meijer A, van der Hoek W, Kretzschmar M, Koopmans M.
Source
Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Abstract
Background. As there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in the elderly attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available.Methods. On weekly time series (1999-2007) we used regression models to associate total death counts in individuals aged 65-74; 75-84, and ≥85 years (a population of 2.5 million), with pathogen circulation: influenza A (season-specific), influenza B, RSV, parainfluenza, enterovirus, rotavirus, norovirus, Campylobacter and Salmonella, adjusted for extreme outdoor temperatures.Results. Influenza A and RSV were significantly associated with mortality in all studied age groups; influenza B, and parainfluenza additionally in those aged 75+ years, and norovirus in those aged 85+ years. The proportion of deaths attributable to seasonal viruses was: 6.8% (85+ years); 4.4% (75-84 years); 1.4% (65-74years), but with great variations between years. There were several years wherein RSV, and occasional years wherein influenza B and parainfluenza had a greater impact on elderly mortality than influenza A.Conclusions. The number of different pathogens associated with mortality in the older population increases with increasing age. Besides influenza A and RSV, also influenza B, parainfluenza and norovirus may contribute substantially to elderly mortality.
PMID:
22723641
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22723641
MORTALITY ATTRIBUTABLE TO 9 COMMON INFECTIONS: significant effect of influenza A, RSV, influenza B, norovirus and parainfluenza in the elderly.
van Asten L, van den Wijngaard C, van Pelt W, van de Kassteele J, Meijer A, van der Hoek W, Kretzschmar M, Koopmans M.
Source
Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Abstract
Background. As there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in the elderly attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available.Methods. On weekly time series (1999-2007) we used regression models to associate total death counts in individuals aged 65-74; 75-84, and ≥85 years (a population of 2.5 million), with pathogen circulation: influenza A (season-specific), influenza B, RSV, parainfluenza, enterovirus, rotavirus, norovirus, Campylobacter and Salmonella, adjusted for extreme outdoor temperatures.Results. Influenza A and RSV were significantly associated with mortality in all studied age groups; influenza B, and parainfluenza additionally in those aged 75+ years, and norovirus in those aged 85+ years. The proportion of deaths attributable to seasonal viruses was: 6.8% (85+ years); 4.4% (75-84 years); 1.4% (65-74years), but with great variations between years. There were several years wherein RSV, and occasional years wherein influenza B and parainfluenza had a greater impact on elderly mortality than influenza A.Conclusions. The number of different pathogens associated with mortality in the older population increases with increasing age. Besides influenza A and RSV, also influenza B, parainfluenza and norovirus may contribute substantially to elderly mortality.
PMID:
22723641
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22723641