tetano
Editor, Senior Moderator
Mov Disord
. 2021 May 4.
doi: 10.1002/mds.28586. Online ahead of print.
Clinical Profiles and Mortality of COVID-19 Inpatients with Parkinson's Disease in Germany
Raphael Scherbaum[SUP] 1 [/SUP], Eun Hae Kwon[SUP] 1 [/SUP], Daniel Richter[SUP] 1 [/SUP], Dirk Bartig[SUP] 2 [/SUP], Ralf Gold[SUP] 1 3 [/SUP], Christos Krogias[SUP] 1 [/SUP], Lars T?nges[SUP] 1 3 [/SUP]
Affiliations
Abstract
Background: Comprehensive, nationwide data regarding Parkinson's disease (PD) hospitalizations, coronavirus disease 2019 (COVID-19) in-hospital frequency, and COVID-19-associated inpatient mortality during the first wave of the COVID-19 pandemic are not available.
Objective: To provide a nationwide analysis on hospitalized PD patients in Germany and evaluate the impact of the COVID-19 pandemic.
Methods: We conducted a cross-sectional study using an administrative claims database covering 1468 hospitals and 5,210,432 patient hospitalizations including a total of 30,872 COVID-19[SUP]+[/SUP] cases between January 16 and May 15, 2020.
Results: Compared to 2019, hospitalizations for PD transiently decreased by up to 72.7% in 2020. COVID-19 frequency was significantly higher in the population of 64,434 PD patients (693 being COVID-19[SUP]+[/SUP] ) than in non-PD patients (1.1% vs. 0.6%, P < 0.001), especially in subjects with advanced age (? 65 years). Regarding established COVID-19 risk comorbidities, COVID-19[SUP]+[/SUP] inpatients with PD showed higher incidences than non-PD COVID-19[SUP]+[/SUP] subjects, particularly hypertension and chronic kidney disease. Advanced age and male sex were significantly more frequent in COVID-19[SUP]+[/SUP] than in COVID-19[SUP]-[/SUP] PD patients. The COVID-19 inpatient mortality rate was much higher in PD patients than in non-PD patients (35.4% vs. 20.7%, P < 0.001), especially in patients aged 75-79 years. Of note, overall inpatient mortality of PD patients was significantly higher in 2020 than in 2019 (5.7% vs. 4.9%, P < 0.001).
Conclusions: PD inpatients are more frequently affected by COVID-19 and suffer from increased COVID-19-associated mortality in comparison to non-PD patients. More comprehensive studies are needed to assess the significance of associated comorbidities for COVID-19 risk and mortality in PD. ? 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keywords: COVID-19 mortality; COVID-19 risk factors; Parkinson's disease; epidemiology; hospitalization.
. 2021 May 4.
doi: 10.1002/mds.28586. Online ahead of print.
Clinical Profiles and Mortality of COVID-19 Inpatients with Parkinson's Disease in Germany
Raphael Scherbaum[SUP] 1 [/SUP], Eun Hae Kwon[SUP] 1 [/SUP], Daniel Richter[SUP] 1 [/SUP], Dirk Bartig[SUP] 2 [/SUP], Ralf Gold[SUP] 1 3 [/SUP], Christos Krogias[SUP] 1 [/SUP], Lars T?nges[SUP] 1 3 [/SUP]
Affiliations
- PMID: 33942924
- DOI: 10.1002/mds.28586
Abstract
Background: Comprehensive, nationwide data regarding Parkinson's disease (PD) hospitalizations, coronavirus disease 2019 (COVID-19) in-hospital frequency, and COVID-19-associated inpatient mortality during the first wave of the COVID-19 pandemic are not available.
Objective: To provide a nationwide analysis on hospitalized PD patients in Germany and evaluate the impact of the COVID-19 pandemic.
Methods: We conducted a cross-sectional study using an administrative claims database covering 1468 hospitals and 5,210,432 patient hospitalizations including a total of 30,872 COVID-19[SUP]+[/SUP] cases between January 16 and May 15, 2020.
Results: Compared to 2019, hospitalizations for PD transiently decreased by up to 72.7% in 2020. COVID-19 frequency was significantly higher in the population of 64,434 PD patients (693 being COVID-19[SUP]+[/SUP] ) than in non-PD patients (1.1% vs. 0.6%, P < 0.001), especially in subjects with advanced age (? 65 years). Regarding established COVID-19 risk comorbidities, COVID-19[SUP]+[/SUP] inpatients with PD showed higher incidences than non-PD COVID-19[SUP]+[/SUP] subjects, particularly hypertension and chronic kidney disease. Advanced age and male sex were significantly more frequent in COVID-19[SUP]+[/SUP] than in COVID-19[SUP]-[/SUP] PD patients. The COVID-19 inpatient mortality rate was much higher in PD patients than in non-PD patients (35.4% vs. 20.7%, P < 0.001), especially in patients aged 75-79 years. Of note, overall inpatient mortality of PD patients was significantly higher in 2020 than in 2019 (5.7% vs. 4.9%, P < 0.001).
Conclusions: PD inpatients are more frequently affected by COVID-19 and suffer from increased COVID-19-associated mortality in comparison to non-PD patients. More comprehensive studies are needed to assess the significance of associated comorbidities for COVID-19 risk and mortality in PD. ? 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Keywords: COVID-19 mortality; COVID-19 risk factors; Parkinson's disease; epidemiology; hospitalization.