tetano
Editor, Senior Moderator
J Stroke Cerebrovasc Dis. 2020 Feb 24:104701. doi: 10.1016/j.jstrokecerebrovasdis.2020.104701. [Epub ahead of print] [h=1]Multiple Border-Zone Infarcts Triggered by Influenza A Virus Infection in a Patient With Cerebral Autosomal Dominant Arteriopathy Presenting With Subcortical Infarcts and Leukoencephalopathy.[/h]
Mizutani K[SUP]1[/SUP], Sakurai K[SUP]2[/SUP], Mizuta I[SUP]3[/SUP], Mizuno T[SUP]3[/SUP], Yuasa H[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) can develop multiple border-zone infarcts due to hypotension, hypovolemia, or surgery. We report the case of a 41-year-old woman with CADASIL who developed multiple border-zone infarcts due to influenza A virus infection. The patient had no apparent history or episode of stroke or altered consciousness following the onset of respiratory symptoms, which were due to the influenza A infection. Diffusion-weighted magnetic resonance images of the brain showed multiple acute-phase infarcts in border-zone areas of both cerebral hemispheres and the corpus callosum; fluid-attenuated inversion-recovery magnetic resonance images showed increased signal in the subcortical areas of both temporal poles. Gene analysis identified a heterozygous mutation c.160C>T in exon 2 of the NOTCH3 gene (p.Arg54Cys). A diagnosis of CADASIL was established. Our case demonstrates that infectious conditions such as influenza A can trigger multiple border-zone infarctions in patients with CADASIL.
Copyright ? 2020 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] CADASIL; border-zone infarcts; corpus callosum.; influenza A infection
PMID: 32102741 DOI: 10.1016/j.jstrokecerebrovasdis.2020.104701
Mizutani K[SUP]1[/SUP], Sakurai K[SUP]2[/SUP], Mizuta I[SUP]3[/SUP], Mizuno T[SUP]3[/SUP], Yuasa H[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) can develop multiple border-zone infarcts due to hypotension, hypovolemia, or surgery. We report the case of a 41-year-old woman with CADASIL who developed multiple border-zone infarcts due to influenza A virus infection. The patient had no apparent history or episode of stroke or altered consciousness following the onset of respiratory symptoms, which were due to the influenza A infection. Diffusion-weighted magnetic resonance images of the brain showed multiple acute-phase infarcts in border-zone areas of both cerebral hemispheres and the corpus callosum; fluid-attenuated inversion-recovery magnetic resonance images showed increased signal in the subcortical areas of both temporal poles. Gene analysis identified a heterozygous mutation c.160C>T in exon 2 of the NOTCH3 gene (p.Arg54Cys). A diagnosis of CADASIL was established. Our case demonstrates that infectious conditions such as influenza A can trigger multiple border-zone infarctions in patients with CADASIL.
Copyright ? 2020 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] CADASIL; border-zone infarcts; corpus callosum.; influenza A infection
PMID: 32102741 DOI: 10.1016/j.jstrokecerebrovasdis.2020.104701