tetano
Editor, Senior Moderator
Muscle Nerve
. 2021 Dec 24.
doi: 10.1002/mus.27482. Online ahead of print.
COVID-19 Infection in Patients with Late-Onset Pompe Disease
Jennifer Avelar[SUP] 1 [/SUP], Marie Wencel[SUP] 1 [/SUP], Anastasia Chumakova[SUP] 1 [/SUP], Tahseen Mozaffar[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction/aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) is frequently more severe in individuals with preexisting respiratory and cardiovascular conditions The impact on patients with neuromuscular disorders is concerning, but largely unknown. Late-onset Pompe disease (LOPD), is a lysosomal storage disorder characterized by progressive skeletal and respiratory muscle degeneration. Mortality is typically caused by respiratory failure. We examined the impact of COVID-19 on these patients.
Methods: This is a case Series of 4 patients with LOPD who contracted COVID-19.
Results: All patients experienced a mild/moderate illness from COVID-19 and did not require hospitalization. Neurological worsening occurred in one; with no change in physical ability in the other three, and respiratory symptoms remained stable in all four.
Discussion: COVID-19 infection can result in a benign course in some patients with LOPD. However, individuals with LOPD remain at high risk and should receive COVID-19 vaccinations and exercise precautions to avoid exposure to COVID-19 infection.
Keywords: COVID-19; Fatigue; Late-Onset Pompe Disease; Pulmonary Disease; SARS-CoV2.
. 2021 Dec 24.
doi: 10.1002/mus.27482. Online ahead of print.
COVID-19 Infection in Patients with Late-Onset Pompe Disease
Jennifer Avelar[SUP] 1 [/SUP], Marie Wencel[SUP] 1 [/SUP], Anastasia Chumakova[SUP] 1 [/SUP], Tahseen Mozaffar[SUP] 1 [/SUP]
Affiliations
- PMID: 34952985
- DOI: 10.1002/mus.27482
Abstract
Introduction/aims: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) is frequently more severe in individuals with preexisting respiratory and cardiovascular conditions The impact on patients with neuromuscular disorders is concerning, but largely unknown. Late-onset Pompe disease (LOPD), is a lysosomal storage disorder characterized by progressive skeletal and respiratory muscle degeneration. Mortality is typically caused by respiratory failure. We examined the impact of COVID-19 on these patients.
Methods: This is a case Series of 4 patients with LOPD who contracted COVID-19.
Results: All patients experienced a mild/moderate illness from COVID-19 and did not require hospitalization. Neurological worsening occurred in one; with no change in physical ability in the other three, and respiratory symptoms remained stable in all four.
Discussion: COVID-19 infection can result in a benign course in some patients with LOPD. However, individuals with LOPD remain at high risk and should receive COVID-19 vaccinations and exercise precautions to avoid exposure to COVID-19 infection.
Keywords: COVID-19; Fatigue; Late-Onset Pompe Disease; Pulmonary Disease; SARS-CoV2.