Giuseppe
Emeritus
[Source: The New England Journal of Medicine, full text: (LINK). Extract, edited.]
Clinical Implications of Basic Research
Stalking Influenza Diversity with a Universal Antibody
Charles J. Russell, Ph.D.
N Engl J Med 2011; 365:1541-1542 October 20, 2011
This article has no abstract; the first 100 words appear below.
The back-and-forth battle between influenza viruses and humans is defined by diversity. We fight previously unseen pathogens with a diverse repertoire of antibodies, and influenza viruses evade our immune system by presenting us with diverse surface-protein sequences. Corti and colleagues have recently discovered a universal influenza antibody, revealing an Achilles' heel common to all influenza strains that we can now target with next-generation antiviral drugs and vaccines.
The current co
untermeasures against seasonal influenza are the use of annual vaccines and antiviral drugs, such as oseltamivir. Seasonal strains (presently, H1N1, H3N2, and B type) evade our immune systems after vaccination or (?)
Disclosure forms provided by the author are available with the full text of this article at NEJM.org.
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Clinical Implications of Basic Research
Stalking Influenza Diversity with a Universal Antibody
Charles J. Russell, Ph.D.
N Engl J Med 2011; 365:1541-1542 October 20, 2011
This article has no abstract; the first 100 words appear below.
The back-and-forth battle between influenza viruses and humans is defined by diversity. We fight previously unseen pathogens with a diverse repertoire of antibodies, and influenza viruses evade our immune system by presenting us with diverse surface-protein sequences. Corti and colleagues have recently discovered a universal influenza antibody, revealing an Achilles' heel common to all influenza strains that we can now target with next-generation antiviral drugs and vaccines.
The current co
untermeasures against seasonal influenza are the use of annual vaccines and antiviral drugs, such as oseltamivir. Seasonal strains (presently, H1N1, H3N2, and B type) evade our immune systems after vaccination or (?)
Disclosure forms provided by the author are available with the full text of this article at NEJM.org.