tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2013 Dec 16;10(3). [Epub ahead of print]
Narcolepsy and A(H1N1)pdm09 vaccination: Shaping the research on the observed signal.
van der Most R, Van Mechelen M, Destexhe E, Wettendorff M, Hanon E.
Author information
Abstract
Epidemiological data from several European countries suggested an increased risk of the chronic sleep disorder narcolepsy following vaccination with Pandemrix?, an AS03-adjuvanted, pandemic A(H1N1)pdm09 influenza vaccine. Further research to investigate potential associations between Pandemrix? vaccination, A(H1N1)pdm09 influenza infection and narcolepsy is required. Narcolepsy is most commonly caused by a reduction or absence of hypocretin produced by hypocretin-secreting neurons in the hypothalamus, and is tightly associated with HLA-II DQB1*0602. Consequently, research focusing on CD4 T-cell responses, building on the hypothesis that for disease development, T cells specific for antigen(s) from hypocretin neurons must be activated or reactivated, is considered essential. Therefore, the following key areas of research can be identified, (1) characterization of hypothetical narcolepsy-specific auto-immune CD4 T cells, (2) mapping epitopes of such T cells, and (3) evaluating potential mechanisms that would enable such cells to gain access to the hypothalamus. Addressing these questions could further our understanding of the potential links between narcolepsy and A(H1N1)pdm09 vaccination and/or infection. Of particular interest is that any evidence of a mimicry-based mechanism could also explain the association between narcolepsy and A(H1N1)pdm09 infection.
KEYWORDS:
A(H1N1)pdm09 influenza, CD4 T cell, Pandemrix, hypocretin, narcolepsy, pandemic, vaccine
PMID:
24342916
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24342916
Narcolepsy and A(H1N1)pdm09 vaccination: Shaping the research on the observed signal.
van der Most R, Van Mechelen M, Destexhe E, Wettendorff M, Hanon E.
Author information
Abstract
Epidemiological data from several European countries suggested an increased risk of the chronic sleep disorder narcolepsy following vaccination with Pandemrix?, an AS03-adjuvanted, pandemic A(H1N1)pdm09 influenza vaccine. Further research to investigate potential associations between Pandemrix? vaccination, A(H1N1)pdm09 influenza infection and narcolepsy is required. Narcolepsy is most commonly caused by a reduction or absence of hypocretin produced by hypocretin-secreting neurons in the hypothalamus, and is tightly associated with HLA-II DQB1*0602. Consequently, research focusing on CD4 T-cell responses, building on the hypothesis that for disease development, T cells specific for antigen(s) from hypocretin neurons must be activated or reactivated, is considered essential. Therefore, the following key areas of research can be identified, (1) characterization of hypothetical narcolepsy-specific auto-immune CD4 T cells, (2) mapping epitopes of such T cells, and (3) evaluating potential mechanisms that would enable such cells to gain access to the hypothalamus. Addressing these questions could further our understanding of the potential links between narcolepsy and A(H1N1)pdm09 vaccination and/or infection. Of particular interest is that any evidence of a mimicry-based mechanism could also explain the association between narcolepsy and A(H1N1)pdm09 infection.
KEYWORDS:
A(H1N1)pdm09 influenza, CD4 T cell, Pandemrix, hypocretin, narcolepsy, pandemic, vaccine
PMID:
24342916
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24342916