tetano
Editor, Senior Moderator
Nat Aging
. 2022 Dec;2(12):1130-1137.
doi: 10.1038/s43587-022-00321-w. Epub 2022 Dec 5. Severe COVID-19 is associated with molecular signatures of aging in the human brain
Maria Mavrikaki[SUP] #[/SUP][SUP] 1 [/SUP], Jonathan D Lee[SUP] #[/SUP][SUP] 2 [/SUP], Isaac H Solomon[SUP] 3 [/SUP], Frank J Slack[SUP] 4 5 [/SUP]
Affiliations
As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive care unit/ventilator treatment. Our findings indicate that COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals.
Maria Mavrikaki[SUP] #[/SUP][SUP] 1 [/SUP], Jonathan D Lee[SUP] #[/SUP][SUP] 2 [/SUP], Isaac H Solomon[SUP] 3 [/SUP], Frank J Slack[SUP] 4 5 [/SUP]
Affiliations
As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive care unit/ventilator treatment. Our findings indicate that COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals.
. 2022 Dec;2(12):1130-1137.
doi: 10.1038/s43587-022-00321-w. Epub 2022 Dec 5. Severe COVID-19 is associated with molecular signatures of aging in the human brain
Maria Mavrikaki[SUP] #[/SUP][SUP] 1 [/SUP], Jonathan D Lee[SUP] #[/SUP][SUP] 2 [/SUP], Isaac H Solomon[SUP] 3 [/SUP], Frank J Slack[SUP] 4 5 [/SUP]
Affiliations
- PMID: 37118539
- DOI: 10.1038/s43587-022-00321-w
As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive care unit/ventilator treatment. Our findings indicate that COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals.
Maria Mavrikaki[SUP] #[/SUP][SUP] 1 [/SUP], Jonathan D Lee[SUP] #[/SUP][SUP] 2 [/SUP], Isaac H Solomon[SUP] 3 [/SUP], Frank J Slack[SUP] 4 5 [/SUP]
Affiliations
- PMID: 37118539
- DOI: 10.1038/s43587-022-00321-w
As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive care unit/ventilator treatment. Our findings indicate that COVID-19 is associated with molecular signatures of brain aging and emphasize the value of neurological follow-up in recovered individuals.