tetano
Editor, Senior Moderator
Nat Biotechnol
. 2021 Dec 20.
doi: 10.1038/s41587-021-01131-y. Online ahead of print.
Single-cell immunology of SARS-CoV-2 infection
Yuan Tian[SUP] 1 2 [/SUP], Lindsay N Carpp[SUP] 1 [/SUP], Helen E R Miller[SUP] 1 [/SUP], Michael Zager[SUP] 3 [/SUP], Evan W Newell[SUP] 4 [/SUP], Raphael Gottardo[SUP] 5 6 7 [/SUP]
Affiliations
Abstract
Gaining a better understanding of the immune cell subsets and molecular factors associated with protective or pathological immunity against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 could aid the development of vaccines and therapeutics for coronavirus disease 2019 (COVID-19). Single-cell technologies, such as flow cytometry, mass cytometry, single-cell transcriptomics and single-cell multi-omic profiling, offer considerable promise in dissecting the heterogeneity of immune responses among individual cells and uncovering the molecular mechanisms of COVID-19 pathogenesis. Single-cell immune-profiling studies reported to date have identified innate and adaptive immune cell subsets that correlate with COVID-19 disease severity, as well as immunological factors and pathways of potential relevance to the development of vaccines and treatments for COVID-19. For facilitation of integrative studies and meta-analyses into the immunology of SARS-CoV-2 infection, we provide standardized, download-ready versions of 21 published single-cell sequencing datasets (over 3.2 million cells in total) as well as an interactive visualization portal for data exploration.
. 2021 Dec 20.
doi: 10.1038/s41587-021-01131-y. Online ahead of print.
Single-cell immunology of SARS-CoV-2 infection
Yuan Tian[SUP] 1 2 [/SUP], Lindsay N Carpp[SUP] 1 [/SUP], Helen E R Miller[SUP] 1 [/SUP], Michael Zager[SUP] 3 [/SUP], Evan W Newell[SUP] 4 [/SUP], Raphael Gottardo[SUP] 5 6 7 [/SUP]
Affiliations
- PMID: 34931002
- DOI: 10.1038/s41587-021-01131-y
Abstract
Gaining a better understanding of the immune cell subsets and molecular factors associated with protective or pathological immunity against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 could aid the development of vaccines and therapeutics for coronavirus disease 2019 (COVID-19). Single-cell technologies, such as flow cytometry, mass cytometry, single-cell transcriptomics and single-cell multi-omic profiling, offer considerable promise in dissecting the heterogeneity of immune responses among individual cells and uncovering the molecular mechanisms of COVID-19 pathogenesis. Single-cell immune-profiling studies reported to date have identified innate and adaptive immune cell subsets that correlate with COVID-19 disease severity, as well as immunological factors and pathways of potential relevance to the development of vaccines and treatments for COVID-19. For facilitation of integrative studies and meta-analyses into the immunology of SARS-CoV-2 infection, we provide standardized, download-ready versions of 21 published single-cell sequencing datasets (over 3.2 million cells in total) as well as an interactive visualization portal for data exploration.