tetano
Editor, Senior Moderator
Nat Commun
. 2026 Jan 16.
doi: 10.1038/s41467-025-67272-9. Online ahead of print.
Estimating COVID-19 incidence and prevalence using lateral flow tests in England and Scotland, 2023-2024
Martyn Fyles[SUP] 1 [/SUP], Jonathon Mellor[SUP] 2 [/SUP], Robert S Paton[SUP] 2 [/SUP], Christopher E Overton[SUP] 2 3 [/SUP], Alexander M Phillips[SUP] 2 4 [/SUP], Alex Glaser[SUP] 2 [/SUP], Thomas Ward[SUP] 2 [/SUP]
Affiliations
SARS-CoV-2 continues to cause substantial morbidity and mortality, particularly in winter. During the SARS-CoV-2 pandemic, community prevalence surveys provided detailed monitoring of infection levels. The Winter Coronavirus (COVID-19) Infection Survey (WCIS), conducted in England and Scotland from the 14[SUP]th[/SUP] November 2023 to the 7[SUP]th[/SUP] March 2024, enabled the UK Health Security Agency to publish fortnightly estimates of community infection levels in England and Scotland. Unlike previous community prevalence surveys, WCIS conducted testing using Lateral Flow Device (LFD) tests, and featured a repeat testing design that enabled estimation of key epidemiological parameters. LFD tests have a substantially lower cost per unit than Polymerase Chain Reaction (PCR) tests which were used in previous SARS-CoV-2 prevalence surveys; however, they have a high false negative rate that must be accounted for to produce reliable estimates. In this manuscript, statistical methods to robustly estimate incidence and prevalence while adjusting for time-varying false negative rates are developed. This enabled timely and robust inference of the incidence and prevalence of SARS-CoV-2, stratified by age group, location and sex. Overall, the study design of WCIS overcame key limitations of earlier large-scale community prevalence studies and demonstrated the utility of LFD tests in infectious disease surveillance.
. 2026 Jan 16.
doi: 10.1038/s41467-025-67272-9. Online ahead of print.
Estimating COVID-19 incidence and prevalence using lateral flow tests in England and Scotland, 2023-2024
Martyn Fyles[SUP] 1 [/SUP], Jonathon Mellor[SUP] 2 [/SUP], Robert S Paton[SUP] 2 [/SUP], Christopher E Overton[SUP] 2 3 [/SUP], Alexander M Phillips[SUP] 2 4 [/SUP], Alex Glaser[SUP] 2 [/SUP], Thomas Ward[SUP] 2 [/SUP]
Affiliations
- PMID: 41545344
- DOI: 10.1038/s41467-025-67272-9
SARS-CoV-2 continues to cause substantial morbidity and mortality, particularly in winter. During the SARS-CoV-2 pandemic, community prevalence surveys provided detailed monitoring of infection levels. The Winter Coronavirus (COVID-19) Infection Survey (WCIS), conducted in England and Scotland from the 14[SUP]th[/SUP] November 2023 to the 7[SUP]th[/SUP] March 2024, enabled the UK Health Security Agency to publish fortnightly estimates of community infection levels in England and Scotland. Unlike previous community prevalence surveys, WCIS conducted testing using Lateral Flow Device (LFD) tests, and featured a repeat testing design that enabled estimation of key epidemiological parameters. LFD tests have a substantially lower cost per unit than Polymerase Chain Reaction (PCR) tests which were used in previous SARS-CoV-2 prevalence surveys; however, they have a high false negative rate that must be accounted for to produce reliable estimates. In this manuscript, statistical methods to robustly estimate incidence and prevalence while adjusting for time-varying false negative rates are developed. This enabled timely and robust inference of the incidence and prevalence of SARS-CoV-2, stratified by age group, location and sex. Overall, the study design of WCIS overcame key limitations of earlier large-scale community prevalence studies and demonstrated the utility of LFD tests in infectious disease surveillance.