tetano
Editor, Senior Moderator
Nat Commun
. 2025 Jan 10;16(1):586.
doi: 10.1038/s41467-025-55823-z. Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Harry Pickering[SUP] #[/SUP][SUP] 1 [/SUP], Joanna Schaenman[SUP] #[/SUP][SUP] 1 [/SUP], Hoang Van Phan[SUP] #[/SUP][SUP] 2 [/SUP], Cole Maguire[SUP] #[/SUP][SUP] 3 [/SUP], Alexandra Tsitsiklis[SUP] 2 [/SUP], Nadine Rouphael[SUP] 4 [/SUP], Nelson Iván Agudelo Higuita[SUP] 5 [/SUP], Mark A Atkinson[SUP] 6 [/SUP], Scott Brakenridge[SUP] 6 [/SUP], Monica Fung[SUP] 2 [/SUP], William Messer[SUP] 7 [/SUP]; IMPACC Network; Ramin Salehi-Rad[SUP] 1 [/SUP], Matthew C Altman[SUP] 8 [/SUP], Patrice M Becker[SUP] 9 [/SUP], Steven E Bosinger[SUP] 4 [/SUP], Walter Eckalbar[SUP] 2 [/SUP], Annmarie Hoch[SUP] 10 [/SUP], Naresh Doni Jayavelu[SUP] 8 [/SUP], Seunghee Kim-Schulze[SUP] 11 [/SUP], Meagan Jenkins[SUP] 1 [/SUP], Steven H Kleinstein[SUP] 12 [/SUP], Florian Krammer[SUP] 11 [/SUP], Holden T Maecker[SUP] 13 [/SUP], Al Ozonoff[SUP] 10 14 15 [/SUP], Joann Diray-Arce[SUP] 10 15 [/SUP], Albert Shaw[SUP] 12 [/SUP], Lindsey Baden[SUP] 15 16 [/SUP], Ofer Levy[SUP] 10 14 15 [/SUP], Elaine F Reed[SUP] 1 [/SUP], Charles R Langelier[SUP] 17 18 [/SUP]
Collaborators, Affiliations
Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls. We find that transplant recipients have higher nasal SARS-CoV-2 viral abundance and impaired viral clearance, and lower anti-spike IgG levels. In addition, transplant recipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells. Blood and nasal transcriptional profiling demonstrate unexpected upregulation of innate immune signaling pathways and increased levels of several proinflammatory serum chemokines. Severe disease in transplant recipients, however, is characterized by a less robust induction of pro-inflammatory genes and chemokines. Together, our study reveals distinct immune features and altered viral dynamics in solid organ transplant recipients.
. 2025 Jan 10;16(1):586.
doi: 10.1038/s41467-025-55823-z. Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Harry Pickering[SUP] #[/SUP][SUP] 1 [/SUP], Joanna Schaenman[SUP] #[/SUP][SUP] 1 [/SUP], Hoang Van Phan[SUP] #[/SUP][SUP] 2 [/SUP], Cole Maguire[SUP] #[/SUP][SUP] 3 [/SUP], Alexandra Tsitsiklis[SUP] 2 [/SUP], Nadine Rouphael[SUP] 4 [/SUP], Nelson Iván Agudelo Higuita[SUP] 5 [/SUP], Mark A Atkinson[SUP] 6 [/SUP], Scott Brakenridge[SUP] 6 [/SUP], Monica Fung[SUP] 2 [/SUP], William Messer[SUP] 7 [/SUP]; IMPACC Network; Ramin Salehi-Rad[SUP] 1 [/SUP], Matthew C Altman[SUP] 8 [/SUP], Patrice M Becker[SUP] 9 [/SUP], Steven E Bosinger[SUP] 4 [/SUP], Walter Eckalbar[SUP] 2 [/SUP], Annmarie Hoch[SUP] 10 [/SUP], Naresh Doni Jayavelu[SUP] 8 [/SUP], Seunghee Kim-Schulze[SUP] 11 [/SUP], Meagan Jenkins[SUP] 1 [/SUP], Steven H Kleinstein[SUP] 12 [/SUP], Florian Krammer[SUP] 11 [/SUP], Holden T Maecker[SUP] 13 [/SUP], Al Ozonoff[SUP] 10 14 15 [/SUP], Joann Diray-Arce[SUP] 10 15 [/SUP], Albert Shaw[SUP] 12 [/SUP], Lindsey Baden[SUP] 15 16 [/SUP], Ofer Levy[SUP] 10 14 15 [/SUP], Elaine F Reed[SUP] 1 [/SUP], Charles R Langelier[SUP] 17 18 [/SUP]
Collaborators, Affiliations
- PMID: 39794319
- PMCID: PMC11723965
- DOI: 10.1038/s41467-025-55823-z
Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls. We find that transplant recipients have higher nasal SARS-CoV-2 viral abundance and impaired viral clearance, and lower anti-spike IgG levels. In addition, transplant recipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells. Blood and nasal transcriptional profiling demonstrate unexpected upregulation of innate immune signaling pathways and increased levels of several proinflammatory serum chemokines. Severe disease in transplant recipients, however, is characterized by a less robust induction of pro-inflammatory genes and chemokines. Together, our study reveals distinct immune features and altered viral dynamics in solid organ transplant recipients.