tetano
Editor, Senior Moderator
Nat Commun
. 2025 Jan 13;16(1):455.
doi: 10.1038/s41467-024-55272-0. Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology
Hiroshi Ueki[SUP] #[/SUP][SUP] 1 2 [/SUP], I-Hsuan Wang[SUP] #[/SUP][SUP] 3 [/SUP], Maki Kiso[SUP] 4 [/SUP], Kenta Horie[SUP] 5 6 [/SUP], Shun Iida[SUP] 7 [/SUP], Sohtaro Mine[SUP] 7 [/SUP], Michiko Ujie[SUP] 4 [/SUP], Hung-Wei Hsu[SUP] 3 [/SUP], Chen-Hui Henry Wu[SUP] 3 8 [/SUP], Masaki Imai[SUP] 4 9 [/SUP], Tadaki Suzuki[SUP] 7 [/SUP], Wataru Kamitani[SUP] 10 [/SUP], Eiryo Kawakami[SUP] 5 6 11 [/SUP], Yoshihiro Kawaoka[SUP] 12 13 14 15 16 [/SUP]
Affiliations
Microthrombus formation is associated with COVID-19 severity; however, the detailed mechanism remains unclear. In this study, we investigated mouse models with severe pneumonia caused by SARS-CoV-2 infection by using our in vivo two-photon imaging system. In the lungs of SARS-CoV-2-infected mice, increased expression of adhesion molecules in intravascular neutrophils prolonged adhesion time to the vessel wall, resulting in platelet aggregation and impaired lung perfusion. Re-analysis of scRNA-seq data from peripheral blood mononuclear cells from COVID-19 cases revealed increased expression levels of CD44 and SELL in neutrophils in severe COVID-19 cases compared to a healthy group, consistent with our observations in the mouse model. These findings suggest that pulmonary perfusion defects caused by neutrophil adhesion to pulmonary vessels contribute to COVID-19 severity.
. 2025 Jan 13;16(1):455.
doi: 10.1038/s41467-024-55272-0. Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology
Hiroshi Ueki[SUP] #[/SUP][SUP] 1 2 [/SUP], I-Hsuan Wang[SUP] #[/SUP][SUP] 3 [/SUP], Maki Kiso[SUP] 4 [/SUP], Kenta Horie[SUP] 5 6 [/SUP], Shun Iida[SUP] 7 [/SUP], Sohtaro Mine[SUP] 7 [/SUP], Michiko Ujie[SUP] 4 [/SUP], Hung-Wei Hsu[SUP] 3 [/SUP], Chen-Hui Henry Wu[SUP] 3 8 [/SUP], Masaki Imai[SUP] 4 9 [/SUP], Tadaki Suzuki[SUP] 7 [/SUP], Wataru Kamitani[SUP] 10 [/SUP], Eiryo Kawakami[SUP] 5 6 11 [/SUP], Yoshihiro Kawaoka[SUP] 12 13 14 15 16 [/SUP]
Affiliations
- PMID: 39805823
- DOI: 10.1038/s41467-024-55272-0
Microthrombus formation is associated with COVID-19 severity; however, the detailed mechanism remains unclear. In this study, we investigated mouse models with severe pneumonia caused by SARS-CoV-2 infection by using our in vivo two-photon imaging system. In the lungs of SARS-CoV-2-infected mice, increased expression of adhesion molecules in intravascular neutrophils prolonged adhesion time to the vessel wall, resulting in platelet aggregation and impaired lung perfusion. Re-analysis of scRNA-seq data from peripheral blood mononuclear cells from COVID-19 cases revealed increased expression levels of CD44 and SELL in neutrophils in severe COVID-19 cases compared to a healthy group, consistent with our observations in the mouse model. These findings suggest that pulmonary perfusion defects caused by neutrophil adhesion to pulmonary vessels contribute to COVID-19 severity.