tetano
Editor, Senior Moderator
Nat Commun
. 2024 Sep 30;15(1):8449.
doi: 10.1038/s41467-024-52404-4. Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection
Patrick M Archambault[SUP] 1 2 3 [/SUP], Rhonda J Rosychuk[SUP] 4 [/SUP], Martyne Audet[SUP] 5 [/SUP], Jeffrey P Hau[SUP] 6 [/SUP], Lorraine Graves[SUP] 7 [/SUP], Simon Décary[SUP] 8 [/SUP], Jeffrey J Perry[SUP] 9 10 [/SUP], Steven C Brooks[SUP] 11 12 [/SUP], Laurie J Morrison[SUP] 13 [/SUP], Raoul Daoust[SUP] 14 15 [/SUP], David Seonguk Yeom[SUP] 6 [/SUP], Hana Wiemer[SUP] 16 [/SUP], Patrick T Fok[SUP] 16 [/SUP], Andrew D McRae[SUP] 17 18 [/SUP], Kavish Chandra[SUP] 19 [/SUP], Michelle E Kho[SUP] 20 21 [/SUP], Dawn Stacey[SUP] 10 22 [/SUP], Bilkis Vissandjée[SUP] 23 [/SUP], Matthew Menear[SUP] 24 25 [/SUP], Eric Mercier[SUP] 24 25 26 27 [/SUP], Samuel Vaillancourt[SUP] 13 28 [/SUP], Samina Aziz[SUP] 29 [/SUP], Dianne Zakaria[SUP] 29 [/SUP], Phil Davis[SUP] 30 [/SUP], Katie N Dainty[SUP] 31 32 [/SUP], Jean-Sébastien Paquette[SUP] 24 25 [/SUP], Murdoch Leeies[SUP] 33 [/SUP], Susie Goulding[SUP] 7 34 [/SUP], Elyse Berger Pelletier[SUP] 24 [/SUP], Corinne M Hohl[SUP] 6 [/SUP]; Canadian COVID−19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group investigators
Collaborators, Affiliations
Symptoms of the Post-COVID-19 Condition are often non-specific making it a challenge to distinguish them from symptoms due to other medical conditions. In this study, we compare the proportion of emergency department patients who developed symptoms consistent with the World Health Organization's Post-COVID-19 Condition clinical case definition between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 infection and time-matched patients who tested negative. Our results show that over one-third of emergency department patients with a proven acute infection meet Post-COVID-19 Condition criteria 3 months post-index visit. However, one in five test-negative patients who claim never having been infected also report symptoms consistent with Post-COVID-19 Condition highlighting the lack of specificity of the clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of Post-COVID-19 Condition become available for diagnosis and treatment.
. 2024 Sep 30;15(1):8449.
doi: 10.1038/s41467-024-52404-4. Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection
Patrick M Archambault[SUP] 1 2 3 [/SUP], Rhonda J Rosychuk[SUP] 4 [/SUP], Martyne Audet[SUP] 5 [/SUP], Jeffrey P Hau[SUP] 6 [/SUP], Lorraine Graves[SUP] 7 [/SUP], Simon Décary[SUP] 8 [/SUP], Jeffrey J Perry[SUP] 9 10 [/SUP], Steven C Brooks[SUP] 11 12 [/SUP], Laurie J Morrison[SUP] 13 [/SUP], Raoul Daoust[SUP] 14 15 [/SUP], David Seonguk Yeom[SUP] 6 [/SUP], Hana Wiemer[SUP] 16 [/SUP], Patrick T Fok[SUP] 16 [/SUP], Andrew D McRae[SUP] 17 18 [/SUP], Kavish Chandra[SUP] 19 [/SUP], Michelle E Kho[SUP] 20 21 [/SUP], Dawn Stacey[SUP] 10 22 [/SUP], Bilkis Vissandjée[SUP] 23 [/SUP], Matthew Menear[SUP] 24 25 [/SUP], Eric Mercier[SUP] 24 25 26 27 [/SUP], Samuel Vaillancourt[SUP] 13 28 [/SUP], Samina Aziz[SUP] 29 [/SUP], Dianne Zakaria[SUP] 29 [/SUP], Phil Davis[SUP] 30 [/SUP], Katie N Dainty[SUP] 31 32 [/SUP], Jean-Sébastien Paquette[SUP] 24 25 [/SUP], Murdoch Leeies[SUP] 33 [/SUP], Susie Goulding[SUP] 7 34 [/SUP], Elyse Berger Pelletier[SUP] 24 [/SUP], Corinne M Hohl[SUP] 6 [/SUP]; Canadian COVID−19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group investigators
Collaborators, Affiliations
- PMID: 39349926
- DOI: 10.1038/s41467-024-52404-4
Symptoms of the Post-COVID-19 Condition are often non-specific making it a challenge to distinguish them from symptoms due to other medical conditions. In this study, we compare the proportion of emergency department patients who developed symptoms consistent with the World Health Organization's Post-COVID-19 Condition clinical case definition between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 infection and time-matched patients who tested negative. Our results show that over one-third of emergency department patients with a proven acute infection meet Post-COVID-19 Condition criteria 3 months post-index visit. However, one in five test-negative patients who claim never having been infected also report symptoms consistent with Post-COVID-19 Condition highlighting the lack of specificity of the clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of Post-COVID-19 Condition become available for diagnosis and treatment.