tetano
Editor, Senior Moderator
Nat Commun
. 2022 Jan 10;13(1):128.
doi: 10.1038/s41467-021-27595-9.
Robust and durable serological response following pediatric SARS-CoV-2 infection
Hanna Renk[SUP] #[/SUP][SUP] 1 [/SUP], Alex Dulovic[SUP] #[/SUP][SUP] 2 [/SUP], Alina Seidel[SUP] #[/SUP][SUP] 3 [/SUP], Matthias Becker[SUP] 2 [/SUP], Dorit Fabricius[SUP] 4 [/SUP], Maria Zernickel[SUP] 4 [/SUP], Daniel Junker[SUP] 2 [/SUP], Rüdiger Groß[SUP] 3 [/SUP], Janis Müller[SUP] 3 [/SUP], Alexander Hilger[SUP] 5 [/SUP], Sebastian F N Bode[SUP] 4 [/SUP], Linus Fritsch[SUP] 5 [/SUP], Pauline Frieh[SUP] 5 [/SUP], Anneke Haddad[SUP] 5 [/SUP], Tessa Görne[SUP] 5 [/SUP], Jonathan Remppis[SUP] 1 [/SUP], Tina Ganzemueller[SUP] 6 [/SUP], Andrea Dietz[SUP] 7 [/SUP], Daniela Huzly[SUP] 8 [/SUP], Hartmut Hengel[SUP] 8 [/SUP], Klaus Kaier[SUP] 9 [/SUP], Susanne Weber[SUP] 9 [/SUP], Eva-Maria Jacobsen[SUP] 4 [/SUP], Philipp D Kaiser[SUP] 2 [/SUP], Bjoern Traenkle[SUP] 2 [/SUP], Ulrich Rothbauer[SUP] 2 [/SUP], Maximilian Stich[SUP] 10 [/SUP], Burkhard Tönshoff[SUP] 10 [/SUP], Georg F Hoffmann[SUP] 10 [/SUP], Barbara Müller[SUP] 11 [/SUP], Carolin Ludwig[SUP] 12 13 14 [/SUP], Bernd Jahrsdörfer[SUP] 12 13 14 [/SUP], Hubert Schrezenmeier[SUP] 12 13 14 [/SUP], Andreas Peter[SUP] 15 [/SUP], Sebastian Hörber[SUP] 15 [/SUP], Thomas Iftner[SUP] 6 [/SUP], Jan Münch[SUP] 3 [/SUP], Thomas Stamminger[SUP] 7 [/SUP], Hans-Jürgen Groß[SUP] 16 [/SUP], Martin Wolkewitz[SUP] 9 [/SUP], Corinna Engel[SUP] 1 17 [/SUP], Weimin Liu[SUP] 18 [/SUP], Marta Rizzi[SUP] 19 [/SUP], Beatrice H Hahn[SUP] 18 [/SUP], Philipp Henneke[SUP] 5 20 [/SUP], Axel R Franz[SUP] 1 17 [/SUP], Klaus-Michael Debatin[SUP] 4 [/SUP], Nicole Schneiderhan-Marra[SUP] 2 [/SUP], Ales Janda[SUP] 4 [/SUP], Roland Elling[SUP] 21 22 [/SUP]
Affiliations
Abstract
The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. Neutralization against wild type SARS-CoV-2 and the Delta VOC are analysed in a pseudotyped virus assay. Children, compared to adults, are five times more likely to be asymptomatic, and have higher specific antibody levels which persist longer (96.2% versus 82.9% still seropositive 11-12 months post infection). Of note, symptomatic and asymptomatic infections induce similar humoral responses in all age groups. SARS-CoV-2 infection occurs independent of HCoV serostatus. Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic infection.
. 2022 Jan 10;13(1):128.
doi: 10.1038/s41467-021-27595-9.
Robust and durable serological response following pediatric SARS-CoV-2 infection
Hanna Renk[SUP] #[/SUP][SUP] 1 [/SUP], Alex Dulovic[SUP] #[/SUP][SUP] 2 [/SUP], Alina Seidel[SUP] #[/SUP][SUP] 3 [/SUP], Matthias Becker[SUP] 2 [/SUP], Dorit Fabricius[SUP] 4 [/SUP], Maria Zernickel[SUP] 4 [/SUP], Daniel Junker[SUP] 2 [/SUP], Rüdiger Groß[SUP] 3 [/SUP], Janis Müller[SUP] 3 [/SUP], Alexander Hilger[SUP] 5 [/SUP], Sebastian F N Bode[SUP] 4 [/SUP], Linus Fritsch[SUP] 5 [/SUP], Pauline Frieh[SUP] 5 [/SUP], Anneke Haddad[SUP] 5 [/SUP], Tessa Görne[SUP] 5 [/SUP], Jonathan Remppis[SUP] 1 [/SUP], Tina Ganzemueller[SUP] 6 [/SUP], Andrea Dietz[SUP] 7 [/SUP], Daniela Huzly[SUP] 8 [/SUP], Hartmut Hengel[SUP] 8 [/SUP], Klaus Kaier[SUP] 9 [/SUP], Susanne Weber[SUP] 9 [/SUP], Eva-Maria Jacobsen[SUP] 4 [/SUP], Philipp D Kaiser[SUP] 2 [/SUP], Bjoern Traenkle[SUP] 2 [/SUP], Ulrich Rothbauer[SUP] 2 [/SUP], Maximilian Stich[SUP] 10 [/SUP], Burkhard Tönshoff[SUP] 10 [/SUP], Georg F Hoffmann[SUP] 10 [/SUP], Barbara Müller[SUP] 11 [/SUP], Carolin Ludwig[SUP] 12 13 14 [/SUP], Bernd Jahrsdörfer[SUP] 12 13 14 [/SUP], Hubert Schrezenmeier[SUP] 12 13 14 [/SUP], Andreas Peter[SUP] 15 [/SUP], Sebastian Hörber[SUP] 15 [/SUP], Thomas Iftner[SUP] 6 [/SUP], Jan Münch[SUP] 3 [/SUP], Thomas Stamminger[SUP] 7 [/SUP], Hans-Jürgen Groß[SUP] 16 [/SUP], Martin Wolkewitz[SUP] 9 [/SUP], Corinna Engel[SUP] 1 17 [/SUP], Weimin Liu[SUP] 18 [/SUP], Marta Rizzi[SUP] 19 [/SUP], Beatrice H Hahn[SUP] 18 [/SUP], Philipp Henneke[SUP] 5 20 [/SUP], Axel R Franz[SUP] 1 17 [/SUP], Klaus-Michael Debatin[SUP] 4 [/SUP], Nicole Schneiderhan-Marra[SUP] 2 [/SUP], Ales Janda[SUP] 4 [/SUP], Roland Elling[SUP] 21 22 [/SUP]
Affiliations
- PMID: 35013206
- DOI: 10.1038/s41467-021-27595-9
Abstract
The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. Neutralization against wild type SARS-CoV-2 and the Delta VOC are analysed in a pseudotyped virus assay. Children, compared to adults, are five times more likely to be asymptomatic, and have higher specific antibody levels which persist longer (96.2% versus 82.9% still seropositive 11-12 months post infection). Of note, symptomatic and asymptomatic infections induce similar humoral responses in all age groups. SARS-CoV-2 infection occurs independent of HCoV serostatus. Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic infection.