tetano
Editor, Senior Moderator
Nat Commun
. 2020 Oct 30;11(1):5493.
doi: 10.1038/s41467-020-19057-5.
SARS-CoV-2 viral load is associated with increased disease severity and mortality
Jesse Fajnzylber[SUP] 1 [/SUP], James Regan[SUP] 1 [/SUP], Kendyll Coxen[SUP] 1 [/SUP], Heather Corry[SUP] 1 [/SUP], Colline Wong[SUP] 1 [/SUP], Alexandra Rosenthal[SUP] 1 [/SUP], Daniel Worrall[SUP] 2 [/SUP], Francoise Giguel[SUP] 3 [/SUP], Alicja Piechocka-Trocha[SUP] 2 [/SUP], Caroline Atyeo[SUP] 2 [/SUP], Stephanie Fischinger[SUP] 2 [/SUP], Andrew Chan[SUP] 3 [/SUP], Keith T Flaherty[SUP] 3 [/SUP], Kathryn Hall[SUP] 3 [/SUP], Michael Dougan[SUP] 3 [/SUP], Edward T Ryan[SUP] 3 [/SUP], Elizabeth Gillespie[SUP] 1 [/SUP], Rida Chishti[SUP] 1 [/SUP], Yijia Li[SUP] 1 [/SUP], Nikolaus Jilg[SUP] 1 3 [/SUP], Dusan Hanidziar[SUP] 3 [/SUP], Rebecca M Baron[SUP] 1 [/SUP], Lindsey Baden[SUP] 1 [/SUP], Athe M Tsibris[SUP] 1 [/SUP], Katrina A Armstrong[SUP] 3 [/SUP], Daniel R Kuritzkes[SUP] 1 [/SUP], Galit Alter[SUP] 2 3 [/SUP], Bruce D Walker[SUP] 2 3 4 [/SUP], Xu Yu[SUP] 2 3 [/SUP], Jonathan Z Li[SUP] 5 [/SUP], Massachusetts Consortium for Pathogen Readiness
Collaborators, Affiliations
Abstract
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored.
. 2020 Oct 30;11(1):5493.
doi: 10.1038/s41467-020-19057-5.
SARS-CoV-2 viral load is associated with increased disease severity and mortality
Jesse Fajnzylber[SUP] 1 [/SUP], James Regan[SUP] 1 [/SUP], Kendyll Coxen[SUP] 1 [/SUP], Heather Corry[SUP] 1 [/SUP], Colline Wong[SUP] 1 [/SUP], Alexandra Rosenthal[SUP] 1 [/SUP], Daniel Worrall[SUP] 2 [/SUP], Francoise Giguel[SUP] 3 [/SUP], Alicja Piechocka-Trocha[SUP] 2 [/SUP], Caroline Atyeo[SUP] 2 [/SUP], Stephanie Fischinger[SUP] 2 [/SUP], Andrew Chan[SUP] 3 [/SUP], Keith T Flaherty[SUP] 3 [/SUP], Kathryn Hall[SUP] 3 [/SUP], Michael Dougan[SUP] 3 [/SUP], Edward T Ryan[SUP] 3 [/SUP], Elizabeth Gillespie[SUP] 1 [/SUP], Rida Chishti[SUP] 1 [/SUP], Yijia Li[SUP] 1 [/SUP], Nikolaus Jilg[SUP] 1 3 [/SUP], Dusan Hanidziar[SUP] 3 [/SUP], Rebecca M Baron[SUP] 1 [/SUP], Lindsey Baden[SUP] 1 [/SUP], Athe M Tsibris[SUP] 1 [/SUP], Katrina A Armstrong[SUP] 3 [/SUP], Daniel R Kuritzkes[SUP] 1 [/SUP], Galit Alter[SUP] 2 3 [/SUP], Bruce D Walker[SUP] 2 3 4 [/SUP], Xu Yu[SUP] 2 3 [/SUP], Jonathan Z Li[SUP] 5 [/SUP], Massachusetts Consortium for Pathogen Readiness
Collaborators, Affiliations
- PMID: 33127906
- DOI: 10.1038/s41467-020-19057-5
Abstract
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored.