tetano
Editor, Senior Moderator
Nat Commun
. 2021 May 21;12(1):3006.
doi: 10.1038/s41467-021-23334-2.
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Kerstin Renner[SUP] 1 [/SUP], Tobias Schwittay[SUP] 1 [/SUP], Sophia Chaabane[SUP] 1 [/SUP], Johanna Gottschling[SUP] 1 [/SUP], Christine M?ller[SUP] 1 [/SUP], Charlotte Tiefenb?ck[SUP] 1 [/SUP], Jan-Niklas Salewski[SUP] 1 [/SUP], Frederike Winter[SUP] 1 2 [/SUP], Simone Buchtler[SUP] 1 [/SUP], Saidou Balam[SUP] 1 [/SUP], Maximilian V Malfertheiner[SUP] 3 [/SUP], Matthias Lubnow[SUP] 3 [/SUP], Dirk Lunz[SUP] 4 [/SUP], Bernhard Graf[SUP] 4 [/SUP], Florian Hitzenbichler[SUP] 5 [/SUP], Frank Hanses[SUP] 5 [/SUP], Hendrik Poeck[SUP] 6 [/SUP], Marina Kreutz[SUP] 6 [/SUP], Evelyn Ors?[SUP] 7 [/SUP], Ralph Burkhardt[SUP] 7 [/SUP], Tanja Niedermair[SUP] 8 9 [/SUP], Christoph Brochhausen[SUP] 8 9 [/SUP], Andr? Gessner[SUP] 10 [/SUP], Bernd Salzberger[SUP] 5 [/SUP], Matthias Mack[SUP] 11 12 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity.
. 2021 May 21;12(1):3006.
doi: 10.1038/s41467-021-23334-2.
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes
Kerstin Renner[SUP] 1 [/SUP], Tobias Schwittay[SUP] 1 [/SUP], Sophia Chaabane[SUP] 1 [/SUP], Johanna Gottschling[SUP] 1 [/SUP], Christine M?ller[SUP] 1 [/SUP], Charlotte Tiefenb?ck[SUP] 1 [/SUP], Jan-Niklas Salewski[SUP] 1 [/SUP], Frederike Winter[SUP] 1 2 [/SUP], Simone Buchtler[SUP] 1 [/SUP], Saidou Balam[SUP] 1 [/SUP], Maximilian V Malfertheiner[SUP] 3 [/SUP], Matthias Lubnow[SUP] 3 [/SUP], Dirk Lunz[SUP] 4 [/SUP], Bernhard Graf[SUP] 4 [/SUP], Florian Hitzenbichler[SUP] 5 [/SUP], Frank Hanses[SUP] 5 [/SUP], Hendrik Poeck[SUP] 6 [/SUP], Marina Kreutz[SUP] 6 [/SUP], Evelyn Ors?[SUP] 7 [/SUP], Ralph Burkhardt[SUP] 7 [/SUP], Tanja Niedermair[SUP] 8 9 [/SUP], Christoph Brochhausen[SUP] 8 9 [/SUP], Andr? Gessner[SUP] 10 [/SUP], Bernd Salzberger[SUP] 5 [/SUP], Matthias Mack[SUP] 11 12 [/SUP]
Affiliations
- PMID: 34021143
- DOI: 10.1038/s41467-021-23334-2
Abstract
Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity.