tetano
Editor, Senior Moderator
Nat Immunol
. 2020 Nov 5.
doi: 10.1038/s41590-020-00826-9. Online ahead of print.
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
Stuart P Weisberg[SUP] 1 [/SUP], Thomas J Connors[SUP] 2 [/SUP], Yun Zhu[SUP] 2 3 [/SUP], Matthew R Baldwin[SUP] 4 [/SUP], Wen-Hsuan Lin[SUP] 1 [/SUP], Sandeep Wontakal[SUP] 1 [/SUP], Peter A Szabo[SUP] 5 [/SUP], Steven B Wells[SUP] 6 [/SUP], Pranay Dogra[SUP] 5 [/SUP], Joshua Gray[SUP] 5 [/SUP], Emma Idzikowski[SUP] 2 [/SUP], Debora Stelitano[SUP] 2 3 7 [/SUP], Francesca T Bovier[SUP] 2 3 7 [/SUP], Julia Davis-Porada[SUP] 8 [/SUP], Rei Matsumoto[SUP] 5 9 [/SUP], Maya Meimei Li Poon[SUP] 5 [/SUP], Michael Chait[SUP] 1 5 [/SUP], Cyrille Mathieu[SUP] 10 [/SUP], Branka Horvat[SUP] 10 [/SUP], Didier Decimo[SUP] 10 [/SUP], Krystalyn E Hudson[SUP] 1 [/SUP], Flavia Dei Zotti[SUP] 1 [/SUP], Zachary C Bitan[SUP] 1 [/SUP], Francesca La Carpia[SUP] 1 [/SUP], Stephen A Ferrara[SUP] 11 [/SUP], Emily Mace[SUP] 2 [/SUP], Joshua Milner[SUP] 2 [/SUP], Anne Moscona[SUP] 2 3 12 13 [/SUP], Eldad Hod[SUP] 1 [/SUP], Matteo Porotto[SUP] 14 15 16 [/SUP], Donna L Farber[SUP] 17 18 19 [/SUP]
Affiliations
Abstract
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age[SUP]1,2[/SUP]. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)[SUP]3-5[/SUP]. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.
. 2020 Nov 5.
doi: 10.1038/s41590-020-00826-9. Online ahead of print.
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
Stuart P Weisberg[SUP] 1 [/SUP], Thomas J Connors[SUP] 2 [/SUP], Yun Zhu[SUP] 2 3 [/SUP], Matthew R Baldwin[SUP] 4 [/SUP], Wen-Hsuan Lin[SUP] 1 [/SUP], Sandeep Wontakal[SUP] 1 [/SUP], Peter A Szabo[SUP] 5 [/SUP], Steven B Wells[SUP] 6 [/SUP], Pranay Dogra[SUP] 5 [/SUP], Joshua Gray[SUP] 5 [/SUP], Emma Idzikowski[SUP] 2 [/SUP], Debora Stelitano[SUP] 2 3 7 [/SUP], Francesca T Bovier[SUP] 2 3 7 [/SUP], Julia Davis-Porada[SUP] 8 [/SUP], Rei Matsumoto[SUP] 5 9 [/SUP], Maya Meimei Li Poon[SUP] 5 [/SUP], Michael Chait[SUP] 1 5 [/SUP], Cyrille Mathieu[SUP] 10 [/SUP], Branka Horvat[SUP] 10 [/SUP], Didier Decimo[SUP] 10 [/SUP], Krystalyn E Hudson[SUP] 1 [/SUP], Flavia Dei Zotti[SUP] 1 [/SUP], Zachary C Bitan[SUP] 1 [/SUP], Francesca La Carpia[SUP] 1 [/SUP], Stephen A Ferrara[SUP] 11 [/SUP], Emily Mace[SUP] 2 [/SUP], Joshua Milner[SUP] 2 [/SUP], Anne Moscona[SUP] 2 3 12 13 [/SUP], Eldad Hod[SUP] 1 [/SUP], Matteo Porotto[SUP] 14 15 16 [/SUP], Donna L Farber[SUP] 17 18 19 [/SUP]
Affiliations
- PMID: 33154590
- DOI: 10.1038/s41590-020-00826-9
Abstract
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age[SUP]1,2[/SUP]. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)[SUP]3-5[/SUP]. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.