tetano
Editor, Senior Moderator
Nat Immunol
. 2023 Apr 27.
doi: 10.1038/s41590-023-01497-y. Online ahead of print. Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2
Yves Zurbuchen[SUP] #[/SUP][SUP] 1 [/SUP], Jan Michler[SUP] #[/SUP][SUP] 2 [/SUP], Patrick Taeschler[SUP] 1 [/SUP], Sarah Adamo[SUP] 1 [/SUP], Carlo Cervia[SUP] 1 [/SUP], Miro E Raeber[SUP] 1 [/SUP], Ilhan E Acar[SUP] 2 [/SUP], Jakob Nilsson[SUP] 1 [/SUP], Klaus Warnatz[SUP] 1 3 4 [/SUP], Michael B Soyka[SUP] 5 [/SUP], Andreas E Moor[SUP] 6 [/SUP], Onur Boyman[SUP] 7 8 [/SUP]
Affiliations
The B cell response to different pathogens uses tailored effector mechanisms and results in functionally specialized memory B (B[SUB]m[/SUB]) cell subsets, including CD21[SUP]+[/SUP] resting, CD21[SUP]-[/SUP]CD27[SUP]+[/SUP] activated and CD21[SUP]-[/SUP]CD27[SUP]-[/SUP] B[SUB]m[/SUB] cells. The interrelatedness between these B[SUB]m[/SUB] cell subsets remains unknown. Here we showed that single severe acute respiratory syndrome coronavirus 2-specific B[SUB]m[/SUB] cell clones showed plasticity upon antigen rechallenge in previously exposed individuals. CD21[SUP]-[/SUP] B[SUB]m[/SUB] cells were the predominant subsets during acute infection and early after severe acute respiratory syndrome coronavirus 2-specific immunization. At months 6 and 12 post-infection, CD21[SUP]+[/SUP] resting B[SUB]m[/SUB] cells were the major B[SUB]m[/SUB] cell subset in the circulation and were also detected in peripheral lymphoid organs, where they carried tissue residency markers. Tracking of individual B cell clones by B cell receptor sequencing revealed that previously fated B[SUB]m[/SUB] cell clones could redifferentiate upon antigen rechallenge into other B[SUB]m[/SUB] cell subsets, including CD21[SUP]-[/SUP]CD27[SUP]-[/SUP] B[SUB]m[/SUB] cells, demonstrating that single B[SUB]m[/SUB] cell clones can adopt functionally different trajectories.
. 2023 Apr 27.
doi: 10.1038/s41590-023-01497-y. Online ahead of print. Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2
Yves Zurbuchen[SUP] #[/SUP][SUP] 1 [/SUP], Jan Michler[SUP] #[/SUP][SUP] 2 [/SUP], Patrick Taeschler[SUP] 1 [/SUP], Sarah Adamo[SUP] 1 [/SUP], Carlo Cervia[SUP] 1 [/SUP], Miro E Raeber[SUP] 1 [/SUP], Ilhan E Acar[SUP] 2 [/SUP], Jakob Nilsson[SUP] 1 [/SUP], Klaus Warnatz[SUP] 1 3 4 [/SUP], Michael B Soyka[SUP] 5 [/SUP], Andreas E Moor[SUP] 6 [/SUP], Onur Boyman[SUP] 7 8 [/SUP]
Affiliations
- PMID: 37106039
- DOI: 10.1038/s41590-023-01497-y
The B cell response to different pathogens uses tailored effector mechanisms and results in functionally specialized memory B (B[SUB]m[/SUB]) cell subsets, including CD21[SUP]+[/SUP] resting, CD21[SUP]-[/SUP]CD27[SUP]+[/SUP] activated and CD21[SUP]-[/SUP]CD27[SUP]-[/SUP] B[SUB]m[/SUB] cells. The interrelatedness between these B[SUB]m[/SUB] cell subsets remains unknown. Here we showed that single severe acute respiratory syndrome coronavirus 2-specific B[SUB]m[/SUB] cell clones showed plasticity upon antigen rechallenge in previously exposed individuals. CD21[SUP]-[/SUP] B[SUB]m[/SUB] cells were the predominant subsets during acute infection and early after severe acute respiratory syndrome coronavirus 2-specific immunization. At months 6 and 12 post-infection, CD21[SUP]+[/SUP] resting B[SUB]m[/SUB] cells were the major B[SUB]m[/SUB] cell subset in the circulation and were also detected in peripheral lymphoid organs, where they carried tissue residency markers. Tracking of individual B cell clones by B cell receptor sequencing revealed that previously fated B[SUB]m[/SUB] cell clones could redifferentiate upon antigen rechallenge into other B[SUB]m[/SUB] cell subsets, including CD21[SUP]-[/SUP]CD27[SUP]-[/SUP] B[SUB]m[/SUB] cells, demonstrating that single B[SUB]m[/SUB] cell clones can adopt functionally different trajectories.